Procedures are given for the use of a mouse-mosquito (Aedes aegypti (L.)) test, and supplementary tests in other mammals, in screening and evaluating compounds for chemotherapeutic activity. Nine of thirteen known insecticides given orally to mice killed mosquitoes feeding on them, including six out of seven compounds known to be effective against cattle grubs. The most active of 19 carbamoyl alkyl phophorodithioates tested was O,O,-dimethyl-S-(N-methylcarbamoylmethyl) phosphorodithioate (Am. Cyanamid 12,880). This had an ED50 in mice, lambs and calves of about 6 mg./kg., with a chemotherapeutic index (LD50/ED50) of about 25 in mice. In lambs and calves, about seven times the ED50 for mosquitoes produced marked toxic symptoms. Structure-activity relationships in the carbamoyl alkyl phosphorodithioates indicated a marked superiority of O,O,-dimethyl compounds over corresponding O,O,-diethyl analogs. The few higher O,O,-alkyls tested were uninteresting. In the O,O-dimethyl series, the unsubstituted carbamoyl group was less than one-twentieth as active as the methyl carbamoyl.
Document Type: Research Article
Publication date: April 1, 1958
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Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.