Antifungal activity of essential oil from Oliveria decumbens Vent and its synergy with amphotricin B

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Many essential oil are known to possess antifungal activity and therefore potentially act as antimycotic agents. The essential oil of Oliveria decumbens Vent was isolated by hydrodistillation. The antifungal activity of this essential oil against 10 isolates of C. albicans and 2 isolates of Aspergillus niger and Aspergillus flavus was evaluated by disc diffusion method and micro broth dilution assay. The synergism between amphotricin B and essential oil was evaluated by checkerboard microtitre assay. This essential oil (0.5 l) exhibited significant antifungal activity against tested fungi (18-29 mm) and showed synergism with amphotricin B against C. albicans (the fractional inhibitory concentration index was ≤0.5). The strong antifungal activity of this essential oil and its synergy with amphotricin B may be useful in treatment. However, further in vivo experiments are required to prove its usefulness in practice.


Document Type: Research Article

Publication date: March 1, 2008

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  • The International Journal of Essential Oil Therapeutics is destined for individuals and establishments that have an interest in the bioactivity of aromatic plants, as well as the potential applications of such activities in human and animal treatment modalities. The Journal publishes a range of pertinent subject matter including in vitro and in vivo research, clinical trials, pilot studies, adverse reaction and drug interaction reports and scientifically based discussion relating to therapeutic applications.
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