Publisher: Elsevier

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Volume 14, Number 1, 5 January 2004

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Editorial Board
pp. CO2-CO2(1)

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Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity
pp. 21-24(4)
Authors: Munchhof, M.J.; Beebe, J.S.; Casavant, J.M.; Cooper, B.A.; Doty, J.L.; Higdon, R.C.; Hillerman, S.M.; Soderstrom, C.I.; Knauth, E.A.; Marx, M.A.; Rossi, A.M.K.; Sobolov, S.B.; Sun, J.

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New orally active PDE4 inhibitors with therapeutic potential
pp. 29-32(4)
Authors: Ochiai, H.; Ishida, A.; Ohtani, T.; Kusumi, K.; Kishikawa, K.; Obata, T.; Nakai, H.; Toda, M.

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Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors
pp. 37-41(5)
Authors: Gilbert, A.M.; Kirisits, M.; Toy, P.; Nunn, D.S.; Failli, A.; Dushin, E.G.; Novikova, E.; Petersen, P.J.; Joseph-McCarthy, D.; McFadyen, I.; Fritz, C.C.

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4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors
pp. 43-46(4)
Authors: Parmee, E.R.; He, J.; Mastracchio, A.; Edmondson, S.D.; Colwell, L.; Eiermann, G.; Feeney, W.P.; Habulihaz, B.; He, H.; Kilburn, R.; Leiting, B.; Lyons, K.; Marsilio, F.; Patel, R.A.; Petrov, A.; Di Salvo, J.; Wu, J.K.; Thornberry, N.A.; Weber, A.E.

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Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
pp. 47-50(4)
Authors: Ma, D.; Wu, W.; Yang, G.; Li, J.; Li, J.; Ye, Q.

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In vitro gene delivery by a novel human calcitonin (hCT)-derived carrier peptide
pp. 51-54(4)
Authors: Krauss, U.; Muller, M.; Stahl, M.; Beck-Sickinger, A.G.

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Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement
pp. 55-58(4)
Authors: Leban, J.; Saeb, W.; Garcia, G.; Baumgartner, R.; Kramer, B.

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Peptide deformylase inhibitors with activity against respiratory tract pathogens
pp. 59-62(4)
Authors: East, S.P.; Beckett, R.P.; Brookings, D.C.; Clements, J.M.; Doel, S.; Keavey, K.; Pain, G.; Smith, H.K.; Thomas, W.; Thompson, A.J.; Todd, R.S.; Whittaker, M.

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Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents
pp. 67-71(5)
Authors: Sharma, V.M.; Adi Seshu, K.V.; Chandra Sekhar, V.; Madan, S.; Vishnu, B.; Babu, P.A.; Vamsee Krishna, C.; Sreenu, J.; Ravi Krishna, V.; Venkateswarlu, A.; Rajagopal, S.; Ajaykumar, R.; Kumar, T.S.

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Novel O-glycosyl amino acid mimetics as building blocks for O-glycopeptides act as inhibitors of galactosidases
pp. 73-75(3)
Authors: Kroger, L.; Henkensmeier, D.; Schafer, A.; Thiem, J.

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Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
pp. 77-79(3)
Authors: Hu, X.; Zhu, J.; Srivathsan, S.; Pei, D.

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The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)
pp. 81-85(5)
Authors: Jagtap, P.G.; Southan, G.J.; Baloglu, E.; Ram, S.; Mabley, J.G.; Marton, A.; Salzman, A.; Szabo, C.

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(4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors
pp. 87-90(4)
Authors: Kim, T.; Hague, A.B.; Lee, T.I.; Lian, B.; Tegley, C.M.; Wang, X.; Burgess, T.L.; Qian, Y.; Ross, S.; Tagari, P.; Lin, C.; Mayeda, C.; Dao, J.; Jordan, S.; Mohr, C.; Cheetham, J.; Viswanadhan, V.; Tasker, A.S.

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Investigation of novel fumagillin analogues as angiogenesis inhibitors
pp. 91-94(4)
Authors: Pyun H.-J.; Fardis, M.; Tario, J.; Yang, C.Y.; Ruckman, J.; Henninger, D.; Jin, H.; Kim, C.U.

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine
pp. 95-98(4)
Authors: Li, J.; DeMello, K.M.L.; Cheng, H.; Sakya, S.M.; Bronk, B.S.; Rafka, R.J.; Jaynes, B.H.; Ziegler, C.B.; Kilroy, C.; Mann, D.W.; Nimz, E.L.; Lynch, M.P.; Haven, M.L.; Kolosko, N.L.; Minich, M.L.; Li, C.; Dutra, J.K.; Rast, B.; Crosson, R.M.; Morton, B.J.; Kirk, G.W.; Callaghan, K.M.; Koss, D.A.; Shavnya, A.; Lund, L.A.; Seibel, S.B.; Petras, C.F.; Silvia, A.

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Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs
pp. 99-102(4)
Authors: Ahmad, S.; Doweyko, L.; Ashfaq, A.; Ferrara, F.N.; Bisaha, S.N.; Schmidt, J.B.; DiMarco, J.; Conder, M.L.; Jenkins-West, T.; Normandin, D.E.; Russell, A.D.; Smith, M.A.; Levesque, P.C.; Lodge, N.J.; Lloyd, J.; Stein, P.D.; Atwal, K.S.

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Synthesis and SAR of potent EGFR/erbB2 dual inhibitors
pp. 111-114(4)
Authors: Zhang, Y.; Cockerill, S.; Guntrip, S.B.; Rusnak, D.; Smith, K.; Vanderwall, D.; Wood, E.; Lackey, K.

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Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol
pp. 115-118(4)
Authors: Richter, R.K.; Mickus, D.E.; Rychnovsky, S.D.; Molinski, T.F.

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives
pp. 119-124(6)
Authors: Beaulieu, P.L.; Bos, M.; Bousquet, Y.; Fazal, G.; Gauthier, J.; Gillard, J.; Goulet, S.; LaPlante, S.; Poupart, M.; Lefebvre, S.; McKercher, G.; Pellerin, C.; Austel, V.; Kukolj, G.

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Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-α2b
pp. 133-136(4)
Authors: Blank, V.C.; Poli, C.; Marder, M.; Roguin, L.P.

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An electrochemical device for the assay of the interaction between a dioxin receptor and its various ligands
pp. 137-141(5)
Authors: Murata, M.; Gonda, H.; Yano, K.; Kuroki, S.; Suzutani, T.; Katayama, Y.

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Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities
pp. 143-145(3)
Authors: Sakoh, H.; Sugimoto, Y.; Imamura, H.; Sakuraba, S.; Jona, H.; Bamba-Nagano, R.; Yamada, K.; Hashizume, T.; Morishima, H.

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Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones
pp. 147-150(4)
Authors: Veinberg, G.; Shestakova, I.; Vorona, M.; Kanepe, I.; Lukevics, E.

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The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors
pp. 151-155(5)
Authors: Lapierre, J.; Ahmed, V.; Chen, M.; Ispahany, M.; Guillemette, J.G.; Taylor, S.D.

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Phenolic thiazoles as novel orally-active neuroprotective agents
pp. 157-160(4)
Authors: Harnett, J.J.; Roubert, V.; Dolo, C.; Charnet, C.; Spinnewyn, B.; Cornet, S.; Rolland, A.; Marin, J.; Bigg, D.; Chabrier, P.

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Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase
pp. 161-165(5)
Authors: Song, A.; Wang, X.; Zhang, J.; Marik, J.; Lebrilla, C.B.; Lam, K.S.

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Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists
pp. 167-170(4)
Authors: Mathes, B.M.; Hudziak, K.J.; Schaus, J.M.; Xu, Y.; Nelson, D.L.; Wainscott, D.B.; Nutter, S.E.; Gough, W.H.; Branchek, T.A.; Zgombick, J.M.; Filla, S.A.

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Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono-O-alkylated derivatives
pp. 171-175(5)
Authors: Regueiro-Ren, A.; Naidu, B.N.; Zheng, X.; Hudyma, T.W.; Connolly, T.P.; Matiskella, J.D.; Zhang, Y.; Kim, O.K.; Sorenson, M.E.; Pucci, M.; Clark, J.; Bronson, J.J.; Ueda, Y.

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Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1
pp. 177-180(4)
Authors: Ahmad, S.; Ngu, K.; Combs, D.W.; Wu, S.C.; Weinstein, D.S.; Liu, W.; Chen, B.; Chandrasena, G.; Dorso, C.R.; Kirby, M.; Atwal, K.S.

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Synthesis and cardiovascular activity of metoprolol analogues
pp. 191-194(4)
Authors: Melgar-Fernandez, R.; Demare, P.; Hong, E.; Rosas, M.A.; Escalante, J.; Munoz-Muniz, O.; Juaristi, E.; Regla, I.

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Conformationally-flexible benzamide analogues as dopamine D3 and 2 receptor ligands
pp. 195-202(8)
Authors: Mach, R.H.; Huang, Y.; Freeman, R.A.; Wu, L.; Vangveravong, S.; Luedtke, R.R.

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Highly potent PDE4 inhibitors with therapeutic potential
pp. 207-210(4)
Authors: Ochiai, H.; Ohtani, T.; Ishida, A.; Kusumi, K.; Kato, M.; Kohno, H.; Kishikawa, K.; Obata, T.; Nakai, H.; Toda, M.

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Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of α-MSH
pp. 211-215(5)
Authors: Vagner, J.; Handl, H.L.; Gillies, R.J.; Hruby, V.J.

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Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-α-d-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits
pp. 225-229(5)
Authors: Winum, J.; Casini, A.; Mincione, F.; Starnotti, M.; Montero, J.; Scozzafava, A.; Supuran, C.T.

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Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
pp. 231-234(4)
Authors: Abbate, F.; Winum, J.; Potter, B.V.L.; Casini, A.; Montero, J.; Scozzafava, A.; Supuran, C.T.

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Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis
pp. 235-238(4)
Authors: Francisco, G.D.; Li, Z.; Albright, J.D.; Eudy, N.H.; Katz, A.H.; Petersen, P.J.; Labthavikul, P.; Singh, G.; Yang, Y.; Rasmussen, B.A.; Lin Y.-I.; Mansour, T.S.

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Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR
pp. 239-243(5)
Authors: Lamar, J.; Hu, J.; Bueno, A.B.; Yang, H.; Guo, D.; Copp, J.D.; McGee, J.; Gitter, B.; Timm, D.; May, P.; McCarthy, J.; Chen S.-H.

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P3 cap modified Phe*-Ala series BACE inhibitors
pp. 245-250(6)
Authors: Chen S.-H.; Lamar, J.; Guo, D.; Kohn, T.; Yang, H.; McGee, J.; Timm, D.; Erickson, J.; Yip, Y.; May, P.; McCarthy, J.

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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor
pp. 251-256(6)
Authors: Yip, Y.; Victor, F.; Lamar, J.; Johnson, R.; Wang, Q.M.; Barket, D.; Glass, J.; Jin, L.; Liu, L.; Venable, D.; Wakulchik, M.; Xie, C.; Heinz, B.; Villarreal, E.; Colacino, J.; Yumibe, N.; Tebbe, M.; Munroe, J.; Chen S.-H.

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P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors
pp. 257-261(5)
Authors: Victor, F.; Lamar, J.; Snyder, N.; Yip, Y.; Guo, D.; Yumibe, N.; Johnson, R.B.; Wang, Q.M.; Glass, J.I.; Chen S.-H.

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Novel P4 truncated tripeptidyl α-ketoamides as HCV protease inhibitors
pp. 263-266(4)
Authors: Lamar, J.; Victor, F.; Snyder, N.; Johnson, R.B.; Wang, Q.M.; Glass, J.I.; Chen S.-H.

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Structure-activity relationships of novel potent MurF inhibitors
pp. 267-270(4)
Authors: Gu, Y.G.; Florjancic, A.S.; Clark, R.F.; Zhang, T.; Cooper, C.S.; Anderson, D.D.; Lerner, C.G.; McCall, J.O.; Cai, Y.; Black-Schaefer, C.L.; Stamper, G.F.; Hajduk, P.J.; Beutel, B.A.

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Synthesis and nicotinic receptor activity of a hydroxylated tropane
pp. 271-273(3)
Authors: Bremner, J.B.; Godfrey, C.A.; Jensen, A.A.; Smith, R.J.

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Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
pp. 275-278(4)
Authors: Catalano, J.G.; Deaton, D.N.; Furfine, E.S.; Hassell, A.M.; McFadyen, R.B.; Miller, A.B.; Miller, L.R.; Shewchuk, L.M.; Willard, D.H.; Wright, L.L.

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Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria
pp. 279-282(4)
Authors: He, H.; Shen, B.; Petersen, P.J.; Weiss, W.J.; Yang, H.Y.; Wang, T.; Dushin, R.G.; Koehn, F.E.; Carter, G.T.

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(2-Amino-phenyl)-amides of -substituted alkanoic acids as new histone deacetylase inhibitors
pp. 283-287(5)
Authors: Vaisburg, A.; Bernstein, N.; Frechette, S.; Allan, M.; Abou-Khalil, E.; Leit, S.; Moradei, O.; Bouchain, G.; Wang, J.; Woo, S.H.; Fournel, M.; Yan, P.T.; Trachy-Bourget, M.; Kalita, A.; Beaulieu, C.; Li, Z.; MacLeod, A.R.; Besterman, J.M.; Delorme, D.

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