Bioorganic and Medicinal Chemistry Letters

Editorial board
pp. CO2-CO2(1)

Contributors to this Issue
pp. vii-viii(2)

Contents List
pp. iii

Graphical Abstracts
pp. 2089-2096(8)

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II
pp. 2097-2100(4)
Authors: Stoermer D.; Liu Q.; Hall M.R.; Flanary J.M.; Thomas A.G.; Rojas C.; Slusher B.S.; Tsukamoto T.

Novel Inhibitors of Procollagen C-Terminal Proteinase. Part 1: Diamino Acid Hydroxamates
pp. 2101-2104(4)
Authors: Delaet N.G.J.; Robinson L.A.; Wilson D.M.; Sullivan R.W.; Bradley E.K.; Dankwardt S.M.; Martin R.L.; Van Wart H.E.; Walker K.A.M.

A low background high-Throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone
pp. 2105-2108(4)
Authors: Leroy E.; Bensel N.; Reymond J.-L.

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus
pp. 2109-2112(4)
Authors: Kerns R.J.; Rybak M.J.; Kaatz G.W.; Vaka F.; Cha R.; Grucz R.G.; Diwadkar V.U.

2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists: further characterization of 3,5-Dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-Trimethyl-propyl) ester and structure-Activity relationships
pp. 2113-2118(6)
Authors: Micheli F.; Di Fabio R.; Bordi F.; Cavallini P.; Cavanni P.; Donati D.; Faedo S.; Maffeis M.; Sabbatini F.M.; Tarzia G.; Tranquillini M.E.

BR96 conjugates of highly potent anthracyclines
pp. 2119-2122(4)
Authors: King H.D.; Staab A.J.; Pham-Kaplita K.; Yurgaitis D.; Firestone R.A.; Lasch S.J.; Trail P.A.

Synthesis of the novel liqustrazine derivatives and Their protective effect on injured vascular endothelial cell damaged by hydrogen peroxide
pp. 2123-2126(4)
Authors: Liu X.; Zhang R.; Xu W.; Li C.; Zhao Q.; Wang X.

Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling
pp. 2127-2130(4)
Authors: Hansen T.M.; Engler M.M.; Forsyth C.J.

A new class of histamine H₃-Receptor antagonists: synthesis and structure-Activity relationships of 7,8,9,10-Tetrahydro-6H-cyclohepta[b]quinolines
pp. 2131-2135(5)
Authors: Turner S.C.; Esbenshade T.A.; Bennani Y.L.; Hancock A.A.

Nicotinyl aspartyl ketones as inhibitors of caspase-3
pp. 2137-2140(4)
Authors: Isabel E.; Black W.C.; Bayly C.I.; Grimm E.L.; Janes M.K.; McKay D.J.; Nicholson D.W.; Rasper D.M.; Renaud J.; Roy S.; Tam J.; Thornberry N.A.; Vaillancourt J.P.; Xanthoudakis S.; Zamboni R.

Fundamental structure-Activity relationships associated with a new structural class of respiratory syncytial virus inhibitor
pp. 2141-2144(4)
Authors: Yu K.-L.; Zhang Y.; Civiello R.L.; Kadow K.F.; Cianci C.; Krystal M.; Meanwell N.A.

Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56^lck inhibitor BMS-243117
pp. 2145-2149(5)
Authors: Das J.; Lin J.; Moquin R.V.; Shen Z.; Spergel S.H.; Wityak J.; Doweyko A.M.; DeFex H.F.; Fang Q.; Pang S.; Pitt S.; Shen D.R.; Schieven G.L.; Barrish J.C.

Bivalent biogenic amine reuptake inhibitors
pp. 2151-2154(4)
Authors: Fandrick K.; Feng X.; Janowsky A.; Johnson R.; Cashman J.R.

(+/-)-2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinolines as a new class of specific bradycardic agents
pp. 2155-2158(4)
Authors: Kubota H.; Kakefuda A.; Watanabe T.; Taguchi Y.; Ishii N.; Masuda N.; Sakamoto S.; Tsukamoto S.-i.

Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties
pp. 2159-2161(3)
Authors: Wiesner J.; Mitsch A.; Jomaa H.; Schlitzer M.

Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity
pp. 2163-2166(4)
Authors: Ortmann R.; Wiesner J.; Reichenberg A.; Henschker D.; Beck E.; Jomaa H.; Schlitzer M.

Muscarinic M₃ receptor antagonists with (2R)-2-[(1R)-3,3-Difluorocyclopentyl]-2-hydroxyphenylacetamide Structures. Part 2
pp. 2167-2172(6)
Authors: Ogino Y.; Ohtake N.; Kobayashi K.; Kimura T.; Fujikawa T.; Hasegawa T.; Noguchi K.; Mase T.

Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics
pp. 2173-2177(5)
Authors: Li P.; Zhang M.; Long Y.-Q.; Peach M.L.; Liu H.; Yang D.; Nicklaus M.; Roller P.P.

N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D₃ receptor antagonists
pp. 2179-2183(5)
Authors: Newman A.H.; Cao J.; Bennett C.J.; Robarge M.J.; Freeman R.A.; Luedtke R.R.

3-Azido-3-deoxy-glycopyranoside derivatives as scaffolds for the synthesis of carbohydrate-Based universal pharmacophore mapping libraries
pp. 2185-2189(5)
Authors: Jain R.; Kamau M.; Wang C.; Ippolito R.; Wang H.; Dulina R.; Anderson J.; Gange D.; Sofia M.J.

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human ₃ adrenergic receptor agonists
pp. 2191-2194(4)
Authors: Sum F.-W.; Wong V.; Han S.; Largis E.; Mulvey R.; Tillett J.

Structure-activity study of novel tricyclic benzazepine arginine vasopressin antagonists
pp. 2195-2198(4)
Authors: Sum F.-W.; Dusza J.; Santos E.D.; Grosu G.; Reich M.; Du X.; Albright J.D.; Chan P.; Coupet J.; Ru X.; Mazandarani H.; Saunders T.

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus
pp. 2199-2203(5)
Authors: Zhang H.-C.; White K.B.; McComsey D.F.; Addo M.F.; Andrade-Gordon P.; Derian C.K.; Oksenberg D.; Maryanoff B.E.

6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors
pp. 2205-2209(5)
Authors: Rao P.N.P.; Amini M.; Li H.; Habeeb A.G.; Knaus E.E.

4-Amino-2-(aryl)-butylbenzamides and Their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK₂) receptor
pp. 2211-2215(5)
Authors: MacKenzie A.R.; Marchington A.P.; Middleton D.S.; Newman S.D.; Selway C.N.; Terrett N.K.

Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents
pp. 2217-2222(6)
Authors: Fei X.; Zheng Q.-H.; Liu X.; Wang J.-Q.; Sun H.B.; Mock B.H.; Stone K.L.; Miller K.D.; Sledge G.W.; Hutchins G.D.

Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis
pp. 2223-2225(3)
Authors: Wu J.-H.; Chang F.-R.; Hayashi K.-i.; Shiraki H.; Liaw C.-C.; Nakanishi Y.; Bastow K.F.; Yu D.; Chen I.-S.; Lee K.-H.

Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents
pp. 2227-2230(4)
Authors: Kim H.Y.; Lee J.S.; Cha J.H.; Pae A.N.; Cho Y.S.; Chang M.H.; Koh H.Y.

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors
pp. 2231-2234(4)
Authors: Finn J.; Mattia K.; Morytko M.; Ram S.; Yang Y.; Wu X.; Mak E.; Gallant P.; Keith D.

Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-Dependent pathway
pp. 2235-2237(3)
Authors: Eastwood E.L.; Schaus S.E.

Enantiotracin
pp. 2239-2240(2)
Authors: McDougal P.G.; Griffin J.H.