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Publisher: Elsevier

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Volume 13, Number 10, 19 May 2003

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Editorial board
pp. CO2-CO2(1)

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Contents List
pp. iii

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Graphical Abstracts
pp. 1609-1621(13)

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Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors
pp. 1623-1626(4)
Authors: Bargota, R.S.; Akhtar, M.; Biggadike, K.; Gani, D.; Allemann, R.K.

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The design of 8,8-Dimethyl[1,6]naphthyridines as potential anticonvulsant agents
pp. 1627-1629(3)
Authors: Austin, N.E.; Hadley, M.S.; Harling, J.D.; Harrington, F.P.; Macdonald, G.J.; Mitchell, D.J.; Riley, G.J.; Stean, T.O.; Stemp, G.; Stratton, S.C.; Thompson, M.; Upton, N.

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Novel synthesis of 2'-O-methylguanosine
pp. 1631-1634(4)
Authors: Chow, S.; Wen, K.; Sanghvi, Y.S.; Theodorakis, E.A.

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Antibacterial activity of quinolone-Macrocycle conjugates
pp. 1635-1638(4)
Authors: Jefferson, E.A.; Swayze, E.E.; Osgood, S.A.; Miyaji, A.; Risen, L.M.; Blyn, L.B.

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Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors
pp. 1639-1643(5)
Authors: Pal, M.; Rao Veeramaneni, V.; Nagabelli, M.; Rao Kalleda, S.; Misra, P.; Rao Casturi, S.; Rao Yeleswarapu, K.

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Inactivation of S-Adenosyl-l-Homocysteine hydrolase with novel 5'-thioadenosine derivatives. Antiviral effects
pp. 1649-1652(4)
Authors: Guillerm, G.; Guillerm, D.; Vandenplas-Vitkowski, C.; Glapski, C.; de Clercq, E.

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A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases
pp. 1653-1656(4)
Authors: Dean, K.E.S.; Klein, G.; Renaudet, O.; Reymond J.-L.

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Design and synthesis of spiro-cyclopentenyl and spiro--dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease
pp. 1657-1660(4)
Authors: Andrews, D.M.; Jones, P.S.; Mills, G.; Hind, S.L.; Slater, M.J.; Trivedi, N.; Wareing, K.J.

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Identification of a novel antiangiogenic agent; 4-(N-Imidazol-2-ylmethyl)amino benzopyran analogues
pp. 1661-1663(3)
Authors: Kim, N.; Lee, S.; Yi, K.Y.; Yoo, S.; Kim, G.; Lee, C.O.; Park, S.H.; Lee, B.H.

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The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production
pp. 1665-1668(4)
Authors: Tullis, J.S.; VanRens, J.C.; Natchus, M.G.; Clark, M.P.; de, B.; Hsieh, L.C.; Janusz, M.J.

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Identification of 2-Aminobenzimidazole dimers as antibacterial agents
pp. 1669-1672(4)
Authors: Seth, P.P.; Jefferson, E.A.; Risen, L.M.; Osgood, S.A.

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2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors
pp. 1673-1677(5)
Authors: Manley, P.J.; Balitza, A.E.; Bilodeau, M.T.; Coll, K.E.; Hartman, G.D.; McFall, R.C.; Rickert, K.W.; Rodman, L.D.; Thomas, K.A.

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Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
pp. 1679-1682(4)
Authors: Sharma, V.M.; Adi Seshu, K.V.; Vamsee Krishna, C.; Prasanna, P.; Chandra Sekhar, V.; Venkateswarlu, A.; Rajagopal, S.; Ajaykumar, R.; Deevi, D.S.; Rao Mamidi, N.V.S.; Rajagopalan, R.

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Identification of potent and broad-Spectrum antibiotics from SAR studies of a synthetic vancomycin analogue
pp. 1683-1686(4)
Authors: Ahrendt, K.A.; Olsen, J.A.; Wakao, M.; Trias, J.; Ellman, J.A.

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Synthesis of beta-Lactamase activated nitric oxide donors
pp. 1687-1690(4)
Authors: Tang, X.; Cai, T.; Wang, P.G.

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Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening
pp. 1691-1694(4)
Authors: Pickett, S.D.; Sherborne, B.S.; Wilkinson, T.; Bennett, J.; Borkakoti, N.; Broadhurst, M.; Hurst, D.; Kilford, I.; McKinnell, M.; Jones, P.S.

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Synthesis of water-Soluble prodrugs of BMS-191011: A maxi-K channel opener targeted for post-stroke neuroprotection
pp. 1695-1698(4)
Authors: Hewawasam, P.; Ding, M.; Chen, N.; King, D.; Knipe, J.; Pajor, L.; Ortiz, A.; Gribkoff, V.K.; Starrett, J.

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Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties
pp. 1699-1703(5)
Authors: Stylianakis, I.; Kolocouris, A.; Kolocouris, N.; Fytas, G.; Foscolos, G.B.; Padalko, E.; Neyts, J.; de Clercq, E.

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New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation
pp. 1705-1708(4)
Authors: de Nanteuil, G.; Lila-Ambroise, C.; Rupin, A.; Vallez, M.; Verbeuren, T.J.

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P-selectin blocking potency of multimeric tyrosine sulfates in vitro and in vivo
pp. 1709-1712(4)
Authors: Pochechueva, T.V.; Ushakova, N.A.; Preobrazhenskaya, M.E.; Nifantiev, N.E.; Tsvetkov, Y.E.; Sablina, M.A.; Tuzikov, A.B.; Bird, M.I.; Rieben, R.; Bovin, N.V.

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Design, synthesis and biological evaluation of hetaryl-nucleoside derivatives as inhibitors of chitin synthase
pp. 1713-1716(4)
Authors: Behr, J.; Gourlain, T.; Helimi, A.; Guillerm, G.

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Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine
pp. 1717-1720(4)
Authors: Li, L.; Kracht, J.; Peng, S.; Bernhardt, G.; Elz, S.; Buschauer, A.

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Solid-Phase synthesis of endothelin receptor antagonists
pp. 1721-1724(4)
Authors: Lange, U.E.W.; Braje, W.M.; Amberg, W.; Kettschau, G.

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Synthesis of fluorinated 1-(3-Morpholin-4-yl-phenyl)-Ethylamines
pp. 1725-1728(4)
Authors: Wu Y.-J.; He, H.; Sun, L.; Wu, D.; Gao, Q.; Li, H.

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EDTA bis-(Methyl tyrosinate): A chelating peptoid peroxynitrite scavenger
pp. 1733-1735(3)
Authors: Fisher, A.E.O.; Naughton, D.P.

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Design and synthesis of novel antihypertensive drugs
pp. 1737-1740(4)
Authors: Moutevelis-Minakakis, P.; Gianni, M.; Stougiannou, H.; Zoumpoulakis, P.; Zoga, A.; Vlahakos, A.D.; Iliodromitis, E.; Mavromoustakos, T.

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Structure-activity relationship of a novel class of naphthyl amide KATP channel openers
pp. 1741-1744(4)
Authors: Turner, S.C.; Carroll, W.A.; White, T.K.; Brune, M.E.; Buckner, S.A.; Gopalakrishnan, M.; Fabiyi, A.; Coghlan, M.J.; Scott, V.E.; Castle, N.A.; Daza, A.V.; Milicic, I.; Sullivan, J.P.

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Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus
pp. 1745-1749(5)
Authors: Kerns, R.J.; Rybak, M.J.; Kaatz, G.W.; Vaka, F.; Cha, R.; Grucz, R.G.; Diwadkar, V.U.; Ward, T.D.

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Synthesis and activity of a C-8 keto pleuromutilin derivative
pp. 1751-1753(3)
Authors: Springer, D.M.; Sorenson, M.E.; Huang, S.; Connolly, T.P.; Bronson, J.J.; Matson, J.A.; Hanson, R.L.; Brzozowski, D.B.; LaPorte, T.L.; Patel, R.N.

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Anilinopyrimidines as novel antituberculosis agents
pp. 1755-1757(3)
Authors: Morgan, J.; Haritakul, R.; Keller, P.A.

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4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists
pp. 1759-1762(4)
Authors: Buttelmann, B.; Alanine, A.; Bourson, A.; Gill, R.; Heitz, M.; Mutel, V.; Pinard, E.; Trube, G.; Wyler, R.

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Non-imidazole heterocyclic histamine H3 receptor antagonists
pp. 1767-1770(4)
Authors: Chai, W.; Breitenbucher, J.G.; Kwok, A.; Li, X.; Wong, V.; Carruthers, N.I.; Lovenberg, T.W.; Mazur, C.; Wilson, S.J.; Axe, F.U.; Jones, T.K.

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Synthesis and in vivo imaging properties of [11C]befloxatone: A novel highly potent positron emission tomography ligand for mono-amine oxidase-A
pp. 1771-1775(5)
Authors: Dolle, F.; Valette, H.; Bramoulle, Y.; Guenther, I.; Fuseau, C.; Coulon, C.; Lartizien, C.; Jegham, S.; George, P.; Curet, O.; Pinquier, J.; Bottlaender, M.

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Multidrug resistance reversal activity of key ningalin analogues
pp. 1777-1781(5)
Authors: Soenen, D.R.; Hwang, I.; Hedrick, M.P.; Boger, D.L.

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Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives
pp. 1783-1786(4)
Authors: Auge, F.; Hornebeck, W.; Decarme, M.; Laronze J.-Y.

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Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase
pp. 1787-1790(4)
Authors: Zheng Q.-H.; Liu, X.; Fei, X.; Wang, J.; Mock, B.H.; Glick-Wilson, B.E.; Sullivan, M.L.; Hutchins, G.D.

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A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.
pp. 1791-1794(4)
Authors: Yang S.-W.; Buivich, A.; Chan, T.; Smith, M.; Lachowicz, J.; Pomponi, S.A.; Wright, A.E.; Mierzwa, R.; Patel, M.; Gullo, V.; Chu, M.

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Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library
pp. 1795-1799(5)
Authors: Lam, P.Y.S.; Adams, J.J.; Clark, C.G.; Calhoun, W.J.; Luettgen, J.M.; Knabb, R.M.; Wexler, R.R.

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5-Aryl thiazolidine-2,4-diones as selective PPAR agonists
pp. 1801-1804(4)
Authors: Koyama, H.; Boueres, J.K.; Han, W.; Metzger, E.J.; Bergman, J.P.; Gratale, D.F.; Miller, D.J.; Tolman, R.L.; MacNaul, K.L.; Berger, J.P.; Doebber, T.W.; Leung, K.; Moller, D.E.; Heck, J.V.; Sahoo, S.P.

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A novel bicyclic ketolide derivative
pp. 1805-1807(3)
Authors: Zhao, Y.; You, Q.; Shen, W.

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Non-Peptide αv3 antagonists. Part 6: Design and synthesis of αv3 antagonists containing a pyridone or pyrazinone central scaffold
pp. 1809-1812(4)
Authors: Breslin, M.J.; Duggan, M.E.; Halczenko, W.; Fernandez-Metzler, C.; Hunt, C.A.; Leu, C.; Merkle, K.M.; Naylor-Olsen, A.M.; Prueksaritanont, T.; Stump, G.; Wallace, A.; Rodan, S.B.; Hutchinson, J.H.

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Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos
pp. 1813-1815(3)
Authors: Wu, J.; Wang, X.; Yi, Y.; Lee K.-H.

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Substituted bridged phenyl piperidines: orally active growth hormone secretagogues
pp. 1817-1820(4)
Authors: Lu, Z.; Tata, J.R.; Cheng, K.; Wei, L.; Chan, W.W.; Butler, B.; Schleim, K.D.; Jacks, T.M.; Hickey, G.; Patchett, A.A.

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Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus
pp. 1821-1824(4)
Authors: Lu, Z.; Raghavan, S.; Bohn, J.; Charest, M.; Stahlhut, M.W.; Rutkowski, C.A.; Simcoe, A.L.; Olsen, D.B.; Schleif, W.A.; Carella, A.; Gabryelski, L.; Jin, L.; Lin, J.H.; Emini, E.; Chapman, K.; Tata, J.R.

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Synthesis, anticholinesterase activity and structure-Activity relationships of m-Aminobenzoic acid derivatives
pp. 1825-1827(3)
Authors: Trujillo-Ferrara, J.; Montoya Cano, L.; Espinoza-Fonseca, M.

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Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches
pp. 1829-1835(7)
Authors: Pearlstein, R.A.; Vaz, R.J.; Kang, J.; Chen, X.; Preobrazhenskaya, M.; Shchekotikhin, A.E.; Korolev, A.M.; Lysenkova, L.N.; Miroshnikova, O.V.; Hendrix, J.; Rampe, D.

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Corrigendum to 'Design, Synthesis, and Neuraminidase Inhibitory Activity of GS-4071 Analogues that Utilize a Novel Hydrophobic Paradigm' - [Bioorg. Med. Chem. Lett. 12 (2002) 3425]
pp. 1837-1837(1)
Authors: Hanessian, S.; Wang, J.; Montgomery, D.; Stoll, V.; Stewart, K.D.; Kati, W.; Maring, C.; Kempt, D.; Hutchins, C.; Laver, W.G.

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