Publisher: Elsevier

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Volume 12, Number 1, 7 January 2002

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Contributors to Issue
pp. v-vi(2)

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Graphical Abstracts
pp. vii-xiii(7)

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DNA cleavage by aromatic amines
pp. 1-4(4)
Authors: Warner, P.M.; Qi, J.; Meng, B.; Li, G.; Xie, L.; El-Shafey, A.; Jones, G.B.

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Phthalazine PDE4 inhibitors. Part 3: The synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor
pp. 5-8(4)
Authors: Napoletano, M.; Norcini, G.; Pellacini, F.; Marchini, F.; Morazzoni, G.; Fattori, R.; Ferlenga, P.; Pradella, L.

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Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents
pp. 9-12(4)
Authors: Cardoso, C.R.; de Brito, F.C.F.; da Silva, K.C.M.; de Miranda, A.L.P.; Fraga, C.A.M.; Barreiro, E.J.

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Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor
pp. 17-19(3)
Authors: Christiansen, L.B.; Wenckens, M.; Bury, P.S.; Gissel, B.; Hansen, B.S.; Thorpe, S.M.; Jacobsen, P.; Kanstrup, A.; Jorgensen, A.S.; Naerum, L.; Wassermann, K.

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Minimal structural requirements for agonist activity of PAR-2 activating peptides
pp. 21-24(4)
Authors: Santagada, V.; Caliendo, G.; Severino, B.; Perissutti, E.; Fiorino, F.; Cicala, C.; de Filippis, V.; Cirino, G.

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Nonpeptide αv3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide
pp. 25-29(5)
Authors: Meissner, R.S.; Perkins, J.J.; Duong, L.T.; Hartman, G.D.; Hoffman, W.F.; Huff, J.R.; Ihle, N.C.; Leu, C.; Nagy, R.M.; Naylor-Olsen, A.; Rodan, G.A.; Rodan, S.B.; Whitman, D.B.; Wesolowski, G.A.; Duggan, M.E.

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Non-Peptide αv3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel -Amino acids as aspartic acid replacements
pp. 31-34(4)
Authors: Coleman, P.J.; Brashear, K.M.; Hunt, C.A.; Hoffman, W.F.; Hutchinson, J.H.; Breslin, M.J.; McVean, C.A.; Askew, B.C.; Hartman, G.D.; Rodan, S.B.; Rodan, G.A.; Leu, C.; Prueksaritanont, T.; Fernandez-Metzler, C.; Ma, B.; Libby, L.A.; Merkle, K.M.; Stump, G.L.; Wallace, A.A.; Lynch, J.J.; Lynch, R.; Duggan, M.E.

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Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors
pp. 35-40(6)
Authors: Graminski, G.F.; Carlson, C.L.; Ziemer, J.R.; Cai, F.; Vermeulen, N.M.J.; Vanderwerf, S.M.; Burns, M.R.

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Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues
pp. 41-44(4)
Authors: Das, J.; Kimball, S.D.; Reid, J.A.; Wang, T.C.; Lau, W.F.; Roberts, D.G.M.; Seiler, S.M.; Schumacher, W.A.; Ogletree, M.L.

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Molecular design and structure-Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
pp. 45-49(5)
Authors: Das, J.; Kimball, S.D.; Hall, S.E.; Han, W.; Iwanowicz, E.; Lin, J.; Moquin, R.V.; Reid, J.A.; Sack, J.S.; Malley, M.F.; Chang, C.Y.; Chong, S.; Wang-Iverson, D.B.; Roberts, D.G.M.; Seiler, S.M.; Schumacher, W.A.; Ogletree, M.L.

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
pp. 51-55(5)
Authors: Boyd, H.F.; Fell, S.C.M.; Hickey, D.M.B.; Ife, R.J.; Leach, C.A.; Macphee, C.H.; Milliner, K.J.; Pinto, I.L.; Rawlings, D.A.; Smith, S.A.; Stansfield, I.G.; Stanway, S.J.; Theobald, C.J.; Whittaker, C.M.

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Copper(II)/H2O2-mediated DNA cleavage: involvement of a copper(III) species in H-atom abstraction of deoxyribose units
pp. 57-60(4)
Authors: Amine, A.; Atmani, Z.; El Hallaoui, A.; Giorgi, M.; Pierrot, M.; Reglier, M.

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3-D QSAR studies on new dibenzyltin(IV) anticancer agents by comparative molecular field analysis (CoMFA)
pp. 61-64(4)
Authors: Samuel, P.M.; Vos, D.; Raveendra, D.; Sarma, J.A.R.P.; Roy, S.

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4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors
pp. 65-68(4)
Authors: Hashimoto, H.; Maeda, K.; Ozawa, K.; Haruta, J.; Wakitani, K.

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New readily accessible peroxides with High Anti-malarial Potency
pp. 69-72(4)
Authors: Murakami, N.; Kawanishi, M.; Itagaki, S.; Horii, T.; Kobayashi, M.

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2'-O,4'-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug
pp. 73-76(4)
Authors: Morita, K.; Hasegawa, C.; Kaneko, M.; Tsutsumi, S.; Sone, J.; Ishikawa, T.; Imanishi, T.; Koizumi, M.

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Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists
pp. 81-84(4)
Authors: Morimoto, H.; Shimadzu, H.; Hosaka, T.; Kawase, Y.; Yasuda, K.; Kikkawa, K.; Yamauchi-Kohno, R.; Yamada, K.

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Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds
pp. 85-88(4)
Authors: Tsuji, K.; Spears, G.W.; Nakamura, K.; Tojo, T.; Seki, N.; Sugiyama, A.; Matsuo, M.

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Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors
pp. 93-96(4)
Authors: Willoughby, C.A.; Hutchins, S.M.; Rosauer, K.G.; Dhar, M.J.; Chapman, K.T.; Chicchi, G.G.; Sadowski, S.; Weinberg, D.H.; Patel, S.; Malkowitz, L.; Di Salvo, J.; Pacholok, S.G.; Cheng, K.

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2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine
pp. 97-99(3)
Authors: Okamoto, A.; Tanaka, K.; Saito, I.

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Potent P1' biphenylmethyl substituted aggrecanase inhibitors
pp. 101-104(4)
Authors: Yao, W.; Chao, M.; Wasserman, Z.R.; Liu, R.; Covington, M.B.; Newton, R.; Christ, D.; Wexler, R.R.; Decicco, C.P.

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