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Publisher: Elsevier

Volume 10, Number 20, 16 October 2000

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Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists
pp. 2247-2250(4)
Authors: Wang, Y.; Chackalamannil, S.; Hu, Z.; Clader, J.W.; Greenlee, W.; Billard, W.; Binch, H.; Crosby, G.; Ruperto, V.; Duffy, R.A.; McQuade, R.; Lachowicz, J.E.

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Differential antibacterial activity of moenomycin analogues on gram-positive bacteria
pp. 2251-2254(4)
Authors: Goldman, R.C.; Baizman, E.R.; Branstrom, A.A.; Longley, C.B.

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Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
pp. 2255-2257(3)
Authors: Kozlowski, J.A.; Lowe, D.B.; Guzik, H.S.; Zhou, G.; Ruperto, V.B.; Duffy, R.A.; McQuade, R.; Crosby, G.; Taylor, L.A.; Billard, W.; Binch, H.; Lachowicz, J.E.

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Analogues of SB-203207 as inhibitors of tRNA synthetases
pp. 2263-2266(4)
Authors: Banwell, M.G.; Crasto, C.F.; Easton, C.J.; Forrest, A.K.; Karoli, T.; March, D.R.; Mensah, L.; Nairn, M.R.; O'Hanlon, P.J.; Oldham, M.D.; Yue, W.

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Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors
pp. 2267-2270(4)
Authors: Llinas-Brunet, M.; Bailey, M.; Fazal, G.; Ghiro, E.; Gorys, V.; Goulet, S.; Halmos, T.; Maurice, R.; Poirier, M.; Poupart, M.; Rancourt, J.; Thibeault, D.; Wernic, D.; Lamarre, D.

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NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain
pp. 2271-2274(4)
Authors: LaPlante, S.R.; Aubry, N.; Bonneau, P.R.; Kukolj, G.; Lamarre, D.; Lefebvre, S.; Li, H.; Llinas-Brunet, M.; Plouffe, C.; Cameron, D.R.

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Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide
pp. 2275-2278(4)
Authors: Andrus, M.B.; Turner, T.M.; Sauna, Z.E.; Ambudkar, S.V.

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Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease
pp. 2279-2282(4)
Authors: Dhanak, D.; Burton, G.; Christmann, L.T.; Darcy, M.G.; Elrod, K.C.; Kaura, A.; Keenan, R.M.; Link, J.O.; Peishoff, C.E.; Shah, D.H.

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Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human 3 adrenergic receptor agonists
pp. 2283-2286(4)
Authors: Parmee, E.R.; Brockunier, L.L.; He, J.; Singh, S.B.; Candelore, M.R.; Cascieri, M.A.; Deng, L.; Liu, Y.; Tota, L.; Wyvratt, M.J.; Fisher, M.H.; Weber, A.E.

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DNA triplex structures are stabilized by the incorporation of 3'-endo blocked pyrimidine nucleosides in the hoogsteen strand
pp. 2287-2289(3)
Authors: Savy, P.; Benhida, R.; Fourrey, J.; Maurisse, R.; Sun, J.

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Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases
pp. 2291-2294(4)
Authors: Edwards, P.D.; Mauger, R.C.; Cottrell, K.; Morris, F.X.; Pine, K.K.; Sylvester, M.A.; Scott, C.W.; Furlong, S.T.

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N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists
pp. 2295-2299(5)
Authors: Tsai, Y.; Dukat, M.; Slassi, A.; MacLean, N.; Demchyshyn, L.; Savage, J.E.; Roth, B.L.; Hufesein, S.; Lee, M.; Glennon, R.A.

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Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic p1-ketoamide moieties
pp. 2305-2309(5)
Authors: Semple, J.E.; Levy, O.E.; Minami, N.K.; Owens, T.D.; Siev, D.V.

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Synthesis of derivatives of NK109, 7-OH Benzo[c]phenanthridine alkaloid, and evaluation of their cytotoxicities and reduction-resistant properties
pp. 2321-2323(3)
Authors: Nakanishi, T.; Masuda, A.; Suwa, M.; Akiyama, Y.; Hoshino-Abe, N.; Suzuki, M.

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Design and synthesis of a novel water soluble benzotetrazepinone
pp. 2325-2327(3)
Authors: Dumont-Hornebeck, B.; Strube, Y.N.; Vasilescu, D.; Jean-Claude, B.J.

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The design and synthesis of novel NK1/NK2 dual antagonists
pp. 2329-2332(4)
Authors: Reichard, G.A.; Ball, Z.T.; Aslanian, R.; Anthes, J.C.; Shih, N.; Piwinski, J.J.

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Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines
pp. 2333-2335(3)
Authors: Ting, P.C.; Lee, J.F.; Anthes, J.C.; Shih, N.; Piwinski, J.J.

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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1
pp. 2337-2341(5)
Authors: Furet, P.; Caravatti, G.; Denholm, A.A.; Faessler, A.; Fretz, H.; Garca-Echeverra, C.; Gay, B.; Irving, E.; Press, N.J.; Rahuel, J.; Schoepfer, J.; Walker, C.V.

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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2
pp. 2343-2346(4)
Authors: Walker, C.V.; Caravatti, G.; Denholm, A.A.; Egerton, J.; Faessler, A.; Furet, P.; Garca-Echeverra, C.; Gay, B.; Irving, E.; Jones, K.; Lambert, A.; Press, N.J.; Woods, J.

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1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors
pp. 2347-2351(5)
Authors: Takeuchi, K.; Bastian, J.A.; Gifford-Moore, D.S.; Harper, R.W.; Miller, S.C.; Mullaney, J.T.; Sall, D.J.; Smith, G.F.; Zhang?, M.; Fisher, M.J.

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Highly sensitive and rapid detection of antibody catalysis by luminescent bacteria
pp. 2353-2356(4)
Authors: Shulman, H.; Eberhard, A.; Eberhard, C.; Ulitzur, S.; Keinan, E.

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Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors
pp. 2357-2360(4)
Authors: Rice, K.D.; Gangloff, A.R.; Kuo, E.Y.; Dener, J.M.; Wang, V.R.; Lum, R.; Newcomb, W.S.; Havel, C.; Putnam, D.; Cregar, L.; Wong, M.; Warne, R.L.

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Dibasic inhibitors of human mast cell tryptase. Part 2: Structure-activity relationships and requirements for potent activity
pp. 2361-2366(6)
Authors: Rice, K.D.; Wang, V.R.; Gangloff, A.R.; Kuo, E.Y.; Dener, J.M.; Newcomb, W.S.; Young, W.B.; Putnam, D.; Cregar, L.; Wong, M.; Simpson, P.J.

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Optimising inhibitors of Trypanothione reductase using solid-phase chemistry
pp. 2367-2369(3)
Authors: Chitkul, B.; Bradley, M.

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Chemical modification of nodulisporic acid A: preliminary structure-activity relationships
pp. 2371-2374(4)
Authors: Meinke, P.T.; Ayer, M.B.; Colletti, S.L.; Li, C.; Lim, J.; Ok, D.; Salva, S.; Schmatz, D.M.; Shih, T.L.; Shoop, W.L.; Warmke, L.M.; Wyvratt, M.J.; Zakson-Aiken, M.; Fisher, M.H.

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Novel heterocycles as selective α1-adrenergic receptor antagonists
pp. 2375-2377(3)
Authors: Li, X.; McCoy, K.A.; Murray, W.V.; Jolliffe, L.; Pulito, V.

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Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists
pp. 2379-2382(4)
Authors: Stark, H.; Ligneau, X.; Sadek, B.; Ganellin, C.R.; Arrang, J.; Schwartz, J.; Schunack, W.

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Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives
pp. 2383-2386(4)
Authors: Jorgensen, A.S.; Jacobsen, P.; Christiansen, L.B.; Bury, P.S.; Kanstrup, A.; Thorpe, S.M.; Naerum, L.; Wassermann, K.

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