Publisher: Elsevier

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Volume 10, Number 1, 3 January 2000

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Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors
pp. 1-4(4)
Authors: Soll, R.M.R.M.; Lu, T.T.; Tomczuk, B.B.; Illig, C.R.C.R.; Fedde, C.C.; Eisennagel, S.S.; Bone, R.R.; Murphy, L.L.; Spurlino, J.J.; Salemme, F.R.F.R.

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Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues
pp. 5-8(4)
Authors: Ye, Z.Z.; Gao, Y.Y.; Bakshi, R.K.R.K.; Chen, M.; Rohrer, S.P.S.P.; Feighner, S.D.S.D.; Pong, S.; Howard, A.D.A.D.; Blake, A.A.; Birzin, E.T.E.T.; Locco, L.L.; Parmar, R.M.R.M.; Chan, W.W.; Schaeffer, J.M.J.M.; Smith, R.G.R.G.; Patchett, A.A.A.A.; Nargund, R.P.R.P.

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Phenanthrenequinone antiretroviral agents
pp. 9-11(3)
Authors: Kraus, G.A.G.A.; Melekhov, A.A.; Carpenter, S.S.; Wannemuhler, Y.Y.; Petrich, J.J.

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A sigma-1 receptor selective analogue of BD1008. a potential substitute for (+)-opioids in sigma receptor binding assays
pp. 17-18(2)
Authors: Maeda, D.Y.D.Y.; Williams, W.W.; Bowen, W.D.W.D.; Coop, A.A.

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Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity
pp. 19-21(3)
Authors: Toth, A.A.; Medgyes, A.A.; Bajza, I.I.; Liptak, A.A.; Batta, G.G.; Kontrohr, T.T.; Peterffy, K.K.; Pozsgay, V.V.

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6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism-based inhibitors of human leukocyte elastase
pp. 27-30(4)
Authors: Kerrigan, J.E.J.E.; Walters, M.C.M.C.; Forrester, K.J.K.J.; Crowder, J.B.J.B.; Christopher, L.J.L.J.

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The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family
pp. 31-34(4)
Authors: Webb, T.R.T.R.; Melman, N.N.; Lvovskiy, D.D.; Ji, X.X.; Jacobson, K.A.K.A.

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Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors
pp. 35-38(4)
Authors: Pascal, Y.Y.; Andrianjara, C.R.C.R.; Auclair, E.E.; Avenel, N.N.; Bertin, B.B.; Calvet, A.A.; Feru, F.F.; Lardon, S.S.; Moodley, I.I.; Ouagued, M.M.; Payne, A.A.; Pruniaux, M.; Szilagyi, C.C.

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Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2
pp. 39-43(5)
Authors: Han, C.K.C.K.; Ahn, S.K.S.K.; Choi, N.S.N.S.; Hong, R.K.R.K.; Moon, S.K.S.K.; Chun, H.S.H.S.; Lee, S.J.S.J.; Kim, J.W.J.W.; Hong, C.I.C.I.; Kim, D.D.; Yoon, J.H.J.H.; No, K.T.K.T.

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Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
pp. 45-48(4)
Authors: Dragovich, P.S.P.S.; Zhou, R.R.; Webber, S.E.S.E.; Prins, T.J.T.J.; Kwok, A.K.A.K.; Okano, K.K.; Fuhrman, S.A.S.A.; Zalman, L.S.L.S.; Maldonado, F.C.F.C.; Brown, E.L.E.L.; Meador, J.W.J.W.; Patick, A.K.A.K.; Ford, C.E.C.E.; Brothers, M.A.M.A.; Binford, S.L.S.L.; Matthews, D.A.D.A.; Ferre, R.A.R.A.; Worland, S.T.S.T.

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Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate
pp. 53-54(2)
Authors: Xu, K.K.; Thornalley, P.J.P.J.

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Synthesis and binding studies of some epibatidine analogues
pp. 55-58(4)
Authors: Radl, S.S.; Hezky, P.P.; Hafner, W.W.; Budesnsky, M.M.; Hejnova, L.L.

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1,1-Dimethylallylcoumarins potently supress both lipopolysaccharide- and interferon--induced nitric oxide generation in mouse macrophage RAW 264.7 cells
pp. 59-62(4)
Authors: Murakami, A.A.; Gao, G.G.; Omura, M.M.; Yano, M.M.; Ito, C.C.; Furukawa, H.H.; Takahashi, D.D.; Koshimizu, K.K.; Ohigashi, H.H.

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Traceless synthesis of benzimidazoles on solid support
pp. 67-70(4)
Author: Mazurov, A.A.

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New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants
pp. 71-74(4)
Authors: Kennis, L.E.J.L.E.J.; Bischoff, F.P.F.P.; Mertens, C.J.C.J.; Love, C.J.C.J.; van den Keybus, F.A.F.F.A.F.; Pieters, S.S.; Braeken, M.M.; Megens, A.A.H.P.A.A.H.P.; Leysen, J.E.J.E.

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Synthesis, radiolabelling and biological characterization of (d)-7-iodo-N-(1-phosphonoethyl)-5-aminomethylquinoxaline-2,3-dione, a glycine-binding site antagonist of NMDA receptors
pp. 75-78(4)
Authors: Ametamey, S.M.S.M.; Kokic, M.M.; Carrey-Remy, N.N.; Blauenstein, P.P.; Willmann, M.M.; Bischoff, S.S.; Schmutz, M.M.; Schubiger, P.A.P.A.; Auberson, Y.P.Y.P.

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Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor
pp. 79-82(4)
Authors: Lu, T.T.; Soll, R.M.R.M.; Illig, C.R.C.R.; Bone, R.R.; Murphy, L.L.; Spurlino, J.J.; Salemme, F.R.F.R.; Tomczuk, B.E.B.E.

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Non-peptidic phenyl-Based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines
pp. 83-85(3)
Authors: Lu, T.T.; Tomczuk, B.B.; Bone, R.R.; Murphy, L.L.; Salemme, F.R.F.R.; Soll, R.M.R.M.

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Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity
pp. 87-90(4)
Authors: Dong, Y.Y.; Venkatachalam, T.K.; Narla, R.K.R.K.; Trieu, V.N.V.N.; Sudbeck, E.A.E.A.; Uckun, F.M.F.M.

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