Publisher: Elsevier

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Volume 9, Number 3, 8 February 1999

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Synthesis of potent and selective inhibitors of human plasma kallikrein
pp. 301-306(6)
Authors: Garrett, G.S.; McPhail, S.J.; Tornheim, K.; Correa, P.E.; McIver, J.M.

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Structure-based design of COX-2 selectivity into flurbiprofen
pp. 307-312(6)
Authors: Bayly, C.I.; Black, W.C.; Leger, S.; Ouimet, N.; Ouellet, M.; Percival, M.D.

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Carbohydroxamido-oxazolidines: antibacterial agents that target lipid a biosynthesis
pp. 313-318(6)
Authors: Chen, M.; Steiner, M.G.; de Laszlo, S.E.; Patchett, A.A.; Anderson, M.S.; Hyland, S.A.; Onishi, H.R.; Silver, L.L.; Raetz, C.R.H.

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Substituted furans as inhibitors of the PDE4 enzyme
pp. 323-326(4)
Authors: Perrier, H.; Bayly, C.; Laliberte, F.; Huang, Z.; Rasori, R.; Robichaud, A.; Girard, Y.; Macdonald, D.

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Novel Series of O-Substituted 8-Quinolines and 4-Benzothiazoles as Potent Antagonists of the Bradykinin B2 Receptors
pp. 327-332(6)
Authors: Heitsch, H.; Wagner, A.; Scholkens, B.A.; Wirth, K.

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New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2, 3 or 5-(α-azolylbenzyl)-1H-indoles
pp. 333-336(4)
Authors: Le Borgne, M.; Marchand, P.; delevoye-Seiller, B.; Robert, J.; Le Baut, G.; Hartmann, R.W.; Palzer, M.

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A ''cephalosporin-like'' cyclic depsipeptide: synthesis and reaction with -lactam-recognizing enzymes
pp. 341-346(6)
Authors: Adediran, S.A.; Cabaret, D.; Pratt, R.F.; Wakselman, M.

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Monocarboxylic-based phosphotyrosyl mimetics in the design of Grb2 SH2 domain inhibitors
pp. 347-352(6)
Authors: Burke, T.R.; Luo, J.; Yao, Z.; Gao, Y.; Zhao, H.; Milne, G.W.A.; Guo, R.; Voigt, J.H.; King, C.R.; Yang, D.

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Periodinates: a new class of protein tyrosine phosphatase inhibitors
pp. 353-356(4)
Authors: Leung, K.W.K.; Posner, B.I.; Just, G.

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Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4'' side chain
pp. 363-368(6)
Authors: Bastian, J.A.; Chirgadze, N.; denney, M.L.; Gifford-Moore, D.S.; Sall, D.J.; Smith, G.F.; Wikel, J.H.

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Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)
pp. 369-374(6)
Authors: Varie, D.L.; Shih, C.; Hay, D.A.; Andis, S.L.; Corbett, T.H.; Gossett, L.S.; Janisse, S.K.; Martinelli, M.J.; Moher, E.D.; Schultz, R.M.; Toth, J.E.

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Synthesis and structure-activity relationships of a series of novel Thiazoles as inhibitors of aminoacyl-tRNA synthetases
pp. 375-380(6)
Authors: Yu, X.Y.; Hill, J.M.; Yu, G.; Wang, W.; Kluge, A.F.; Wendler, P.; Gallant, P.

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Synthesis and Biological Evaluation of 1α,24-Dihydroxy-25-nitrovitamin D3
pp. 381-384(4)
Authors: Oshida, J.; Okamoto, M.; Ishizuka, S.; Azuma, S.

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Nucleosides and Nucleotides. 183. Synthesis of 4'α-Branched Thymidines as a New Type of Antiviral Agent
pp. 385-388(4)
Authors: Sugimoto, I.; Shuto, S.; Mori, S.; Shigeta, S.; Matsuda, A.

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Modulation of Multidrug Resistance in Tumor Cells by Taxinine Derivatives
pp. 389-394(6)
Authors: Hosoyama, H.; Shigemori, H.; Tomida, A.; Tsuruo, T.; Kobayashi, J.

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Proof that the actVI genetic region of streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin
pp. 395-400(6)
Authors: Ichinose, K.; Surti, C.; Taguchi, T.; Malpartida, F.; Booker-Milburn, K.I.; Stephenson, G.R.; Ebizuka, Y.; Hopwood, D.A.

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Synthesis and thromboxane A2 antagonistic activity of indane derivatives
pp. 401-406(6)
Authors: Shinozaki, K.; Sato, H.; Iwakuma, T.; Sato, R.; Kurimoto, T.; Yoshida, K.

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The synthesis and evaluation of temperature sensitive tubulin toxins
pp. 407-412(6)
Authors: Miller, T.A.; Bulman, A.L.; Thompson, C.D.; Macdonald, T.L.

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On the relationship of OSW-1 to the cephalostatins
pp. 419-424(6)
Authors: Guo, C.; LaCour, T.G.; Fuchs, P.L.

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New Lead Compounds for Brassinosteroid Biosynthesis Inhibitors
pp. 425-430(6)
Authors: Min, Y.K.; Asami, T.; Fujioka, S.; Murofushi, N.; Yamaguchi, I.; Yoshida, S.

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Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin
pp. 431-436(6)
Authors: Pass, M.; Bolton, R.E.; Coote, S.J.; Finch, H.; Hindley, S.; Lowdon, A.; McDonald, E.; McLaren, J.; Owen, M.; Pegg, N.A.; Mooney, C.J.; Tang, C.; Parry, S.; Patel, C.

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Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors
pp. 437-442(6)
Authors: Vendeville, S.; Bourel, L.; Davioud-Charvet, E.; Grellier, P.; deprez, B.; Sergheraert, C.

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Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones
pp. 443-448(6)
Authors: Jarvest, R.L.; Pinto, I.L.; Ashman, S.M.; Dabrowski, C.E.; Fernandez, A.V.; Jennings, L.J.; Lavery, P.; Tew, D.G.

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Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism
pp. 449-452(4)
Authors: Pinto, I.L.; Jarvest, R.L.; Clarke, B.; Dabrowski, C.E.; Fenwick, A.; Gorczyca, M.M.; Jennings, L.J.; Lavery, P.; Sternberg, E.J.; Tew, D.G.; West, A.

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Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate
pp. 453-458(6)
Authors: Marwood, R.D.; Riley, A.M.; Correa, V.; Taylor, C.W.; Potter, B.V.L.

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Cleavage of the Cyclohexyl-Subunit of Rapamycin results in Loss of immunosuppressive Activity
pp. 459-462(4)
Authors: Sedrani, R.; Jones, L.H.; Jutzi-Eme, A.; Schuler, W.; Cottens, S.

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The design of non-peptide human bradykinin B2 receptor antagonists employing the benzodiazepine peptidomimetic scaffold
pp. 463-468(6)
Authors: Dziadulewicz, E.K.; Brown, M.C.; Dunstan, A.R.; Lee, W.; Said, N.B.; Garratt, P.J.

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Novel cytokine release inhibitors. Part IV: analogs of podocarpic acid
pp. 469-474(6)
Authors: He, W.; Gavai, A.; Huang, F.; Regan, J.; Hanney, B.; Poli, G.; Bruno, J.; Chan, W.K.; Djuri, S.W.; Yu, K.; Zilberstein, A.

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Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: optimization of the C-2 side chain
pp. 475-480(6)
Authors: Britton, T.C.; Spinazze, P.G.; Hipskind, P.A.; Zimmerman, D.M.; Zarrinmayeh, H.; Schober, D.A.; Gehlert, D.R.; Bruns, R.F.

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Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization
pp. 491-496(6)
Authors: Pasternak, A.; Pan, Y.; Marino, D.; Sanderson, P.E.; Mosley, R.; Rohrer, S.P.; Birzin, E.T.; Huskey, S.; Jacks, T.; Schleim, K.D.; Cheng, K.; Schaeffer, J.M.; Patchett, A.A.; Yang, L.

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Diamine preparation for synthesis of a water soluble Ni(II) salen complex
pp. 501-504(4)
Authors: Shearer, J.M.; Rokita, S.E.

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