Bioorganic and Medicinal Chemistry Letters

Synthesis of potent and selective inhibitors of human plasma kallikrein
pp. 301-306(6)
Authors: Garrett G.S.; McPhail S.J.; Tornheim K.; Correa P.E.; McIver J.M.

Structure-based design of COX-2 selectivity into flurbiprofen
pp. 307-312(6)
Authors: Bayly C.I.; Black W.C.; Leger S.; Ouimet N.; Ouellet M.; Percival M.D.

Carbohydroxamido-oxazolidines: antibacterial agents that target lipid a biosynthesis
pp. 313-318(6)
Authors: Chen M.-H.; Steiner M.G.; de Laszlo S.E.; Patchett A.A.; Anderson M.S.; Hyland S.A.; Onishi H.R.; Silver L.L.; Raetz C.R.H.

Synthesis and hybridization property of an oligonucleotide containing a 3'-thioformacetal linked pentathymidylate
pp. 319-322(4)
Authors: Zhang J.; Shaw J.T.; Matteucci M.D.

Substituted furans as inhibitors of the PDE4 enzyme
pp. 323-326(4)
Authors: Perrier H.; Bayly C.; Laliberte F.; Huang Z.; Rasori R.; Robichaud A.; Girard Y.; Macdonald D.

Novel Series of O-Substituted 8-Quinolines and 4-Benzothiazoles as Potent Antagonists of the Bradykinin B₂ Receptors
pp. 327-332(6)
Authors: Heitsch H.; Wagner A.; Scholkens B.A.; Wirth K.

New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2, 3 or 5-(-azolylbenzyl)-1H-indoles
pp. 333-336(4)
Authors: Le Borgne M.; Marchand P.; Delevoye-Seiller B.; Robert J.-M.; Le Baut G.; Hartmann R.W.; Palzer M.

Quantitative analysis of the kinetics of phospholipase A₂ using fast atom bombardment mass spectrometry
pp. 337-340(4)
Authors: Isomura S.; Ito K.; Haruna M.

A ''cephalosporin-like'' cyclic depsipeptide: synthesis and reaction with -lactam-recognizing enzymes
pp. 341-346(6)
Authors: Adediran S.A.; Cabaret D.; Pratt R.F.; Wakselman M.

Monocarboxylic-based phosphotyrosyl mimetics in the design of Grb2 SH2 domain inhibitors
pp. 347-352(6)
Authors: Burke T.R.; Luo J.; Yao Z.-J.; Gao Y.; Zhao H.; Milne G.W.A.; Guo R.; Voigt J.H.; King C.R.; Yang D.

Periodinates: a new class of protein tyrosine phosphatase inhibitors
pp. 353-356(4)
Authors: Leung K.W.K.; Posner B.I.; Just G.

The LMC delta opioid recognition pharmacophore: comparison of SNC80 and oxymorphindole
pp. 357-362(6)
Authors: Coop A.; Jacobson A.E.

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4'' side chain
pp. 363-368(6)
Authors: Bastian J.A.; Chirgadze N.; Denney M.L.; Gifford-Moore D.S.; Sall D.J.; Smith G.F.; Wikel J.H.

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)
pp. 369-374(6)
Authors: Varie D.L.; Shih C.; Hay D.A.; Andis S.L.; Corbett T.H.; Gossett L.S.; Janisse S.K.; Martinelli M.J.; Moher E.D.; Schultz R.M.; Toth J.E.

Synthesis and structure-activity relationships of a series of novel Thiazoles as inhibitors of aminoacyl-tRNA synthetases
pp. 375-380(6)
Authors: Yu X.Y.; Hill J.M.; Yu G.; Wang W.; Kluge A.F.; Wendler P.; Gallant P.

Synthesis and Biological Evaluation of 1,24-Dihydroxy-25-nitrovitamin D₃
pp. 381-384(4)
Authors: Oshida J.-i.; Okamoto M.; Ishizuka S.; Azuma S.

Nucleosides and Nucleotides. 183. Synthesis of 4'-Branched Thymidines as a New Type of Antiviral Agent
pp. 385-388(4)
Authors: Sugimoto I.; Shuto S.; Mori S.; Shigeta S.; Matsuda A.

Modulation of Multidrug Resistance in Tumor Cells by Taxinine Derivatives
pp. 389-394(6)
Authors: Hosoyama H.; Shigemori H.; Tomida A.; Tsuruo T.; Kobayashi J.

Proof that the actVI genetic region of streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin
pp. 395-400(6)
Authors: Ichinose K.; Surti C.; Taguchi T.; Malpartida F.; Booker-Milburn K.I.; Stephenson G.R.; Ebizuka Y.; Hopwood D.A.

Synthesis and thromboxane A₂ antagonistic activity of indane derivatives
pp. 401-406(6)
Authors: Shinozaki K.; Sato H.; Iwakuma T.; Sato R.; Kurimoto T.; Yoshida K.

The synthesis and evaluation of temperature sensitive tubulin toxins
pp. 407-412(6)
Authors: Miller T.A.; Bulman A.L.; Thompson C.D.; Macdonald T.L.

Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors
pp. 413-418(6)
Authors: Iijima K.; Katada J.; Hayashi Y.

On the relationship of OSW-1 to the cephalostatins
pp. 419-424(6)
Authors: Guo C.; LaCour T.G.; Fuchs P.L.

New Lead Compounds for Brassinosteroid Biosynthesis Inhibitors
pp. 425-430(6)
Authors: Min Y.K.; Asami T.; Fujioka S.; Murofushi N.; Yamaguchi I.; Yoshida S.

Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin
pp. 431-436(6)
Authors: Pass M.; Bolton R.E.; Coote S.J.; Finch H.; Hindley S.; Lowdon A.; McDonald E.; McLaren J.; Owen M.; Pegg N.A.; Mooney C.J.; Tang C.-M.; Parry S.; Patel C.

Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors
pp. 437-442(6)
Authors: Vendeville S.; Bourel L.; Davioud-Charvet E.; Grellier P.; Deprez B.; Sergheraert C.

Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones
pp. 443-448(6)
Authors: Jarvest R.L.; Pinto I.L.; Ashman S.M.; Dabrowski C.E.; Fernandez A.V.; Jennings L.J.; Lavery P.; Tew D.G.

Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism
pp. 449-452(4)
Authors: Pinto I.L.; Jarvest R.L.; Clarke B.; Dabrowski C.E.; Fenwick A.; Gorczyca M.M.; Jennings L.J.; Lavery P.; Sternberg E.J.; Tew D.G.; West A.

Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate
pp. 453-458(6)
Authors: Marwood R.D.; Riley A.M.; Correa V.; Taylor C.W.; Potter B.V.L.

Cleavage of the Cyclohexyl-Subunit of Rapamycin results in Loss of immunosuppressive Activity
pp. 459-462(4)
Authors: Sedrani R.; Jones L.H.; Jutzi-Eme A.-M.; Schuler W.; Cottens S.

The design of non-peptide human bradykinin B₂ receptor antagonists employing the benzodiazepine peptidomimetic scaffold
pp. 463-468(6)
Authors: Dziadulewicz E.K.; Brown M.C.; Dunstan A.R.; Lee W.; Said N.B.; Garratt P.J.

Novel cytokine release inhibitors. Part IV: analogs of podocarpic acid
pp. 469-474(6)
Authors: He W.; Gavai A.; Huang F.-C.; Regan J.; Hanney B.; Poli G.; Bruno J.; Chan W.K.; Djuri S.W.; Yu K.-T.; Zilberstein A.

Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: optimization of the C-2 side chain
pp. 475-480(6)
Authors: Britton T.C.; Spinazze P.G.; Hipskind P.A.; Zimmerman D.M.; Zarrinmayeh H.; Schober D.A.; Gehlert D.R.; Bruns R.F.

Comparative molecular field analysis (COMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the ₂-adrenoceptor: the development of new, highly selective inhibitors of PNMT
pp. 481-486(6)
Authors: Grunewald G.L.; Caldwell T.M.; Dahanukar V.H.; Jalluri R.K.; Criscione K.R.

A highly efficient preparation of neoglycoconjugate vaccines using subcarriers that bear clustered carbohydrate antigens
pp. 487-490(4)
Authors: Zhang J.; Kovac P.

Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization
pp. 491-496(6)
Authors: Pasternak A.; Pan Y.; Marino D.; Sanderson P.E.; Mosley R.; Rohrer S.P.; Birzin E.T.; Huskey S.-E.W.; Jacks T.; Schleim K.D.; Cheng K.; Schaeffer J.M.; Patchett A.A.; Yang L.

Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: synthesis of all four stereoisomers and their assay against serine proteases
pp. 497-500(4)
Authors: Abell A.D.; Oldham M.D.

Diamine preparation for synthesis of a water soluble Ni(II) salen complex
pp. 501-504(4)
Authors: Shearer J.M.; Rokita S.E.

The synthesis and P388 cytotoxicity of mycalazol 11 and related 5-acyl-2-hydroxymethylpyrroles
pp. 505-508(4)
Authors: Nabbs B.K.; Abell A.D.