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Publisher: Elsevier

Volume 7, Number 1, 7 January 1997

Bis-quinolinium cyclophanes: a novel class of potent blockers of the apamin-sensitive Ca2+-activated K+ channel
pp. 7-10(4)
Authors: Rosa, J.C.; Beckwith-Hall, B.M.; Galanakis, D.; Ganellin, C.R.; Dunn, P.M.; Jenkinson, D.H.

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SAR for MHC Class II Binding Tetrapeptides: Correlation With Potential Binding Site
pp. 19-24(6)
Authors: Cunningham, B.R.; Rivetna, M.; Tolman, R.L.; Flattery, S.J.; Nichols, E.A.; Schwartz, C.D.; Wicker, L.S.; Hermes, J.D.; Jones, A.B.

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The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)
pp. 25-30(6)
Authors: Calligaro, D.O.; Fairhurst, J.; Hotten, T.M.; Moore, N.A.; Tupper, D.E.

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2,3-substituted 2-azanorbornanes as polar -turn mimetics
pp. 31-36(6)
Authors: Horwell, D.C.; Naylor, D.; Willems, H.M.G.

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Structure-activity studies of CTL inhibitory peptides derived from HLA class I molecules
pp. 37-40(4)
Authors: Schwartz, E.J.; Goldberg, J.; Clayberger, C.; Krensky, A.M.; Griffin, J.H.

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α-((tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1 converting enzyme (ICE)
pp. 41-46(6)
Authors: Graybill, T.L.; Prouty, C.P.; Speier, G.J.; Hoyer, D.; Dolle, R.E.; Helaszek, C.T.; Ator, M.A.; Uhl, J.; Strasters, J.

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Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
pp. 47-52(6)
Authors: Therien, M.; Brideau, C.; Chi, C.C.; Cromlish, W.A.; Gauthier, J.Y.; Gordon, R.; Greig, G.; Kargman, S.; Cheuk, K.L.; Leblanc, Y.; Chun-Sing, L.; O'Neill, G.P.; Riendeau, D.; Roy, P.; Zhaoyin, W.; Lijing, X.; Prasit, P.

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Characterization of the in vitro oxidative metabolites of the cox-2 selective inhibitor L-766,112
pp. 53-56(4)
Authors: Trimble, L.A.; Chauret, N.; Silva, J.M.; Nicoll-Griffith, D.A.; Chun-Sing, L.; Yergey, J.A.

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A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles
pp. 57-62(6)
Authors: Roy, P.; Leblanc, Y.; Ball, R.G.; Brideau, C.; Chan, C.C.; Chauret, N.; Cromlish, W.; Ethier, D.; Gauthier, J.Y.; Gordon, R.; Greig, G.; Guay, J.; Kargman, S.; Lau, C.K.; O'Neill, G.; Silva, J.; Therien, M.; van Staden, C.; E., W.; L., X.; Prasit, P.

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Highly preferential cleavage of unpaired guanines in DNA by a functionalized salen-nickel complex
pp. 63-66(4)
Authors: Routier, S.; Bernier, J.; Catteau, J.; Bailly, C.

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Synthesis, evaluation, and crystallographic analysis of L-371,912: a potent and selective active-site thrombin inhibitor
pp. 67-72(6)
Authors: Lyle, T.A.; Chen, Z.; Appleby, S.D.; Freidinger, R.M.; Gardell, S.J.; Lewis, S.D.; Ying, L.; Lyle, E.A.; Lynch, J.J.; Mulichak, A.M.; Ng, A.S.; Naylor-Olsen, A.M.; Sanders, W.M.

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S1 heterocyclic thrombin inhibitors
pp. 79-84(6)
Authors: Dominguez, C.; Carini, D.J.; Weber, P.C.; Knabb, R.M.; Alexander, R.S.; Kettner, C.A.; Wexler, R.R.

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Synthesis and hepatoprotective effects of soyasapogenol B derivatives
pp. 85-88(4)
Authors: Sasaki, K.; Minowa, N.; Kuzuhara, H.; Nishiyama, S.; Omoto, S.

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Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)
pp. 89-94(6)
Authors: Hlasta, D.J.; Bode, D.C.; Court, J.J.; desai, R.C.; Pagani, E.D.; Silver, P.J.

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Combinatorial epitope search: pitfalls of library design
pp. 95-98(4)
Authors: Zhiguang, Y.; Yen-Ho, C.

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