Bioorganic and Medicinal Chemistry Letters

Isosteric replacement of the indole nucleus by benzothiophene in a series of pyrido[2,3-b]indoles with potential anxiolytic activity
pp. 2589-2592(4)
Authors: Blackburn T.P.; Davies D.T.; Forbes I.T.; Hayward C.J.; Johnson C.N.; Martin R.T.; Piper D.C.; Thomas D.R.; Thompson M.; Upton N.; Ward R.W.

Inhibitors of human collagenase: dipeptide mimetics with lactam and azalactam moieties at the P₂'P₃' position
pp. 2593-2598(6)
Authors: Bird J.; Harper G.P.; Hughes I.; Hunter D.J.; Karran E.H.; Markwell R.E.; Miles-Williams A.J.; Rahman S.S.; Ward R.W.

Synthesis and Antiviral Evaluation of Enantiomeric 2',3'-Dideoxy-and 2',3'-Didehydro-2',3'-dideoxy-4'-Thionucleosides.
pp. 2599-2604(6)
Authors: Young R.J.; Shaw-Ponter S.; Thomson J.B.; Miller J.A.; Cumming J.G.; Pugh A.W.; Rider P.

Balanced AT₁ and AT₂ angiotensin II antagonists. I. new orally active 5-carboxyl imidazolyl biphenyl sulfonylureas.
pp. 2605-2610(6)
Authors: Deprez P.; Heckmann B.; Corbier A.; Vevert J.-P.; Fortin M.; Guillaume J.

Balanced AT₁ and AT₂ angiotensin II antagonists. II. Potent 5 -hydroxyacid imidazolyl biphenyl sulfonylureas
pp. 2611-2616(6)
Authors: Deprez P.; Guillaume J.; Corbier A.; Fortin M.; Vevert J.-P.; Heckmann B.

Balanced AT₁ and AT₂ angiotensin II antagonists. III. Potent and orally active 5--ketosulfoxide imidazolyl biphenyl sulfonylureas.
pp. 2617-2622(6)
Authors: Deprez P.; Guillaume J.; Corbier A.; Vevert J.-P.; Fortin M.; Heckmann B.

Rational design, synthesis, and X-ray structure of renin inhibitors with extended P₁ sidechains
pp. 2623-2626(4)
Authors: Lefker B.A.; Hada W.A.; Wright A.S.; Martin W.H.; Stock I.A.; Schulte G.K.; Pandit J.; Danley D.E.; Ammirati M.J.; Sneddon S.F.

Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors
pp. 2627-2632(6)
Authors: Tellier F.; Acher F.; Brabet I.; Pin J.-P.; Bockaert J.; Azerad R.

The synthesis and biological evaluation of hypericin analogs
pp. 2633-2636(4)
Authors: Kraus G.A.; Zhang W.

Spiroketal Glycomimetics: The Synthesis of a Conformationally Restrained Sialyl Lewis X Mimic.
pp. 2637-2642(6)
Authors: Birkbeck A.A.; Ley S.V.; Prodger J.C.

Tetramic acids as novel glycine site antagonists
pp. 2643-2648(6)
Authors: Mawer I.M.; Kulagowski J.J.; Leeson P.D.; Grimwood S.; Marshall G.R.

The discovery of a series of new non-indole 5HT_1D agonists
pp. 2649-2654(6)
Authors: Van Lommen G.; De Bruyn M.; Schroven M.; Verschueren W.; Janssens W.; Verrelst J.; Leysen J.

Inhibition of glycosidases by substituted amidines
pp. 2655-2660(6)
Authors: Bleriot Y.; Dintinger T.; Genre-Grandpierre A.; Padrines M.; Tellier C.

Phospho-serine and phospho-threonine building blocks for the synthesis of phosphorylated peptides by the FMOC solid phase strategy
pp. 2661-2664(4)
Authors: Vorherr T.; Bannwarth W.

4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT₁ antagonists with improved affinity for the AT₂ receptor
pp. 2665-2670(6)
Authors: Mederski W.W.K.R.; Dorsch D.; Osswald M.; Beier N.; Lues I.; Minck K.-O.; Schelling P.; Ladstetter B.J.

Spiro-piperidine non-peptide neurokinin-1 receptor antagonists
pp. 2671-2676(6)
Authors: Armour D.R.; Watson S.P.; Pegg N.A.; Heron N.M.; Middlemiss D.; C. C.; Cholerton T.J.; Hubbard T.; Vinader M.V.; Davies H.G.; Cocker J.D.; Bays D.E.; Ward P.

Local constrained shifty pseudopeptides inhibitors of ras-farnesyl transferase
pp. 2677-2682(6)
Authors: Byk G.; Duchesne M.; Parker F.; Lelievre Y.; Guitton J.D.; Clerc F.F.; Becquart J.; Tocque B.; Scherman D.

Chemical modification and structure-activity relationships of pyripyropenes; potent, bioavailable inhibitor of acyl-CoA: cholesterol O-acyltransferase(ACAT)
pp. 2683-2688(6)
Authors: Obata R.; Sunazuka T.; Tomoda H.; Harigaya Y.; Omura S.

Development of Fluorescence-Emitting Antibody Labeling Substance by Near-Infrared Ray Excitation
pp. 2689-2694(6)
Authors: Ito S.; Muguruma N.; Kakehashi Y.; Hayashi S.; Okamura S.; Shibata H.; Okahisa T.; Kanamori M.; Shibamura S.; Takesako K.; Nozawa M.; Ishida K.; Shiga M.

Synthesis of novel 20-oxo-pregnacalciferol analogs with binding affinity to the progesterone receptor
pp. 2695-2700(6)
Authors: Perlman K.L.; Darwish H.M.; DeLuca H.F.; Sicinski R.R.

Synthesis and evaluation of synthetic analogues of dolichyl-p-p-chitobiose as oligosaccharyltransferase substrates.
pp. 2701-2706(6)
Authors: Xinggao F.; Gibbs B.S.; Coward J.K.

Cycloalkylpiperazines as HIV-1 Protease Inhibitors: Enhanced Oral Absorption
pp. 2707-2712(6)
Authors: Kim B.M.; Evans B.E.; Gilbert K.F.; Hanifin C.M.; Vacca J.P.; Michelson S.R.; Darke P.L.; Zugay J.A.; Emini E.A.; Schleif W.; Lin J.H.; Chen I.-W.; Vastag K.; Anderson P.S.; Huff J.R.

Synthesis and biological evaluation of an alkenyldiarylmethane (ADAM) which acts as a novel non-nucleoside HIV-1 reverse transcriptase inhibitor
pp. 2713-2716(4)
Authors: Cushman M.; Golebiewski M.; Buckheit R.W.; Graham L.; Rice W.G.

6,3'-dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties.
pp. 2717-2720(4)
Authors: Marder M.; Viola H.; Wasowski C.; Wolfman C.; Waterman P.G.; Medina J.H.; Paladini A.C.

Synthesis and incorporation of 2'-amino acid conjugated nucleotides into ribozymes
pp. 2721-2724(4)
Authors: Matulic-Adamic J.; Beigelman L.; Dudycz L.W.; Gonzalez C.; Usman N.

Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease
pp. 2725-2728(4)
Authors: Kempf D.J.; Flentge C.A.; Wideburg N.E.; Saldivar A.; Vasavanonda S.; Norbeck D.W.

Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids
pp. 2729-2734(6)
Authors: Beard R.L.; Colon D.F.; Klein E.S.; Vorse K.A.; Chandraratna R.A.S.

Structural Factors Affecting the Kinetics of O,N-Acyl Transfer in Potential O-Peptide Prodrugs
pp. 2735-2740(6)
Authors: Oliyai R.; Stella V.J.

Novel C-4 Paclitaxel (Taxol(R)) Analogs: Potent Antitumor Agents
pp. 2741-2746(6)
Authors: Shu-Hui C.; Jian-Mei W.; Long B.H.; Fairchild C.A.; Carboni J.; Mamber S.W.; Rose W.C.; Johnston K.; Casazza A.M.; Kadow J.F.; Farina V.; Vyas D.M.; Doyle T.W.

6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones via a diels-alder reaction:antagonists with a non-planar hydrophobic region for NMDA receptor glycine sites
pp. 2747-2748(2)
Authors: Guzikowski A.P.; Hawkinson J.; Weber E.; Keana J.F.W.

Synthesis of dibenzo[a,d]cycloheptanes as cytokine biosynthesis inhibitors
pp. 2749-2754(6)
Authors: Ting P.C.; Lee J.F.; Solomon D.M.; Smith S.R.; Terminelli C.A.; Jakway J.P.; Zambas D.N.

Inhibition of an HIV-1 tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics
pp. 2755-2760(6)
Authors: Houng-Yau M.; Galan A.A.; Halim N.S.; Mack D.P.; Moreland D.W.; Sanders K.B.; Truong H.N.; Czarnik A.W.

Phenyl-Glycinol Based NK₁ Receptor Antagonists - Towards the Minimum Pharmacophore
pp. 2761-2766(6)
Authors: Owens A.P.; Williams B.J.; Harrison T.; Swain C.J.; Baker R.; Sadowski S.; Cascieri M.A.