Publisher: Elsevier

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Volume 19, Number 1, May 2003

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Editorial Board
pp. ii-ii(1)

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Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing
pp. 1-11(11)
Authors: Combes, R.D.; Berridge, T.; Connelly, J.; Eve, M.D.; Garner, R.C.; Toon, S.; Wilcox, P.

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Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives
pp. 13-22(10)
Authors: Schaddelee, M.P.; Voorwinden, H.L.; van Tilburg, E.W.; Pateman, T.J.; Ijzerman, A.P.; Danhof, M.; de Boer, A.G.

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Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects
pp. 23-29(7)
Authors: Monkkonen, H.; Tormalehto, S.; Asunmaa, K.; Niemi, R.; Auriola, S.; Vepsalainen, J.; Monkkonen, J.

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Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes
pp. 31-36(6)
Authors: Jappinen, A.; Turpeinen, M.; Kokki, H.; Rasi, A.; Ojanen, T.; Pelkonen, O.; Naaranlahti, T.

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Anandamide prodrugs - 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide
pp. 37-43(7)
Authors: Juntunen, J.; Huuskonen, J.; Laine, K.; Niemi, R.; Taipale, H.; Nevalainen, T.; Pate, D.W.; Jarvinen, T.

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Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers
pp. 57-65(9)
Authors: Engman, H.; Tannergren, C.; Artursson, P.; Lennernas, H.

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Development and characterization of naproxen-chitosan solid systems with improved drug dissolution properties
pp. 67-75(9)
Authors: Mura, P.; Zerrouk, N.; Mennini, N.; Maestrelli, F.; Chemtob, C.

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Calendar
pp. 79-81(3)

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