Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells

Authors: Shimizu S.; Shiota K.; Yamamoto S.; Miyasaka Y.; Ishii M.; Watabe T.; Nishida M.; Mori Y.; Yamamoto T.; Kiuchi Y.

Source: Free Radical Biology and Medicine, Volume 34, Number 10, 15 May 2003 , pp. 1343-1352(10)

Publisher: Elsevier

Keywords: H₂O₂; Tetrahydrobiopterin; GTP-cyclohydrolase I; NO synthase; Vascular endothelial cells; Free radicals

Language: English

Document Type: Research article

DOI: http://dx.doi.org/10.1016/S0891-5849(03)00172-2

Affiliations: 1: Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, , Tokyo, Japan

Publication date: 2003-05-15

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Medicine (General)
• By this author: Shimizu S. ;  Shiota K. ;  Yamamoto S. ;  Miyasaka Y. ;  Ishii M. ;  Watabe T. ;  Nishida M. ;  Mori Y. ;  Yamamoto T. ;  Kiuchi Y.

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