LC-¹H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems

Authors: Mortensen R.W.¹; Corcoran O.; Cornett C.; Sidelmann U.G.; Troke J.; Lindon J.C.; Nicholson J.K.; Hansen S.H.

Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 24, Number 3, January 2001 , pp. 477-485(9)

Publisher: Elsevier

Keywords: HPLC-NMR; Glucuronide; Acyl-migration; HPLC elution order; S-naproxen; Reactive metabolites

Language: English

Document Type: Research article

DOI: 10.1016/S0731-7085(00)00453-2

Affiliations: 1: aDepartment of Analytical and Pharmaceutical Chemistry, Royal Danish School of Pharmacy, 2, Universitetsparken, DK-2100 , Copenhagen, Denmark

Links for this article

http://www.ingentaconnect.com/els/07317085/2001/00000024/00000003/art00453
http://openurl.ingenta.com/content?genre=article&issn=0731-7085&volume=24&issue=3&spage=477&epage=485
http://dx.doi.org/10.1016/S0731-7085(00)00453-2

LC-1H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems

LC-¹H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems