Metronidazole twin ester prodrugs: synthesis, physicochemical properties, hydrolysis kinetics and antigiardial activity

Authors: Mahfouz N.M.¹; Aboul-Fadl T.; Diab A.K.

Source: European Journal of Medicinal Chemistry, Volume 33, Number 9, September 1998 , pp. 675-683(9)

Publisher: Elsevier

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Keywords: metronidazole; identical twin prodrugs; lipophilicity; hydrolysis kinetics; in vivo evaluation; antigiardial activity

Language: English

Document Type: Research article

DOI: 10.1016/S0223-5234(98)80026-3

Affiliations: 1: Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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