Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats

Authors: Ogawara K.-i.; Furumoto K.; Takakura Y.; Hashida M.; Higaki K.; Kimura T.

Source: Journal of Controlled Release, Volume 77, Number 3, 13 December 2001 , pp. 191-198(8)

Publisher: Elsevier

Keywords: Polystyrene microsphere; Serum proteins; Surface hydrophobicity; Pharmacokinetics; Hepatic uptake

Language: English

Document Type: Research article

DOI: http://dx.doi.org/10.1016/S0168-3659(01)00468-0

Affiliations: 1: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 700-8530, Okayama, Japan

Publication date: 2001-12-13

• In this: publication
• By this: publisher
• In this Subject: Chemical Engineering ,  Pharmacology
• By this author: Ogawara K.-i. ;  Furumoto K. ;  Takakura Y. ;  Hashida M. ;  Higaki K. ;  Kimura T.

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