Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonic prodrug based on the Osteotropic Drug Delivery System (ODDS)

Authors: Hirabayashi H.¹; Takahashi T.; Fujisaki J.; Masunaga T.; Sato S.; Hiroi J.; Tokunaga Y.; Kimura S.; Hata T.

Source: Journal of Controlled Release, Volume 70, Number 1, 29 January 2001 , pp. 183-191(9)

Publisher: Elsevier

Keywords: Osteotropic drug delivery system; Biphosphonate; Prodrug; Diclofenac; Rat adjuvant

Language: English

Document Type: Research article

DOI: 10.1016/S0168-3659(00)00355-2

Affiliations: 1: aBiopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Company, 1-6, Kashima 2-chome, Yodogawa-ku, 532-8514, Osaka, Japan

Links for this article

http://www.ingentaconnect.com/els/01683659/2001/00000070/00000001/art00355
http://openurl.ingenta.com/content?genre=article&issn=0168-3659&volume=70&issue=1&spage=183&epage=191
http://dx.doi.org/10.1016/S0168-3659(00)00355-2