Asymmetric synthesis of (S)-ibuprofen by esterification with amides of (S)-lactic acid as chiral auxiliaries: experimental and theoretical results

Authors: Ammazzalorso A.; Amoroso R.1; Bettoni G.; De Filippis B.; Giampietro L.; Pierini M.; Tricca M.L.

Source: Tetrahedron Letters, Volume 43, Number 24, 10 June 2002 , pp. 4325-4328(4)

Publisher: Elsevier

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Keywords: (S)-ibuprofen; dynamic kinetic resolution; lactamides; molecular mechanic calculations

Language: English

Document Type: Short communication

DOI: 10.1016/S0040-4039(02)00792-X

Affiliations: 1: Dipartimento di Scienze del Farmaco, Universita ''G. D'Annunzio'', Via dei Vestini, 66100 , Chieti, Italy

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