Neighbouring-group participation as the key step in the reactivity of acyclic and cyclic salicyl-derived O,O-acetals with 5-fluorouracil. Antiproliferative activity, cell cycle dysregulation and apoptotic induction of new O,N-acetals against breast cancer cells

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Keywords: acetals; antitumour compounds; benzodioxepins; mechanisms; neighbouring group effects

Document Type: Research Article


Affiliations: Departamento de Quimica Farmaceutica y Organica, Facultad de Farmacia, c/ Campus de Cartuja s/n, 18071 , Granada, Spain

Publication date: September 29, 2003

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