Synthesis of 2'-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified oligonucleotides: hybridization affinity, resistance to nuclease, and protein binding characteristics

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Keywords: hybridization affinity; nuclease resistance; protein binding

Document Type: Research Article


Affiliations: Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., 2280 Faraday Ave, 92008, Carlsbad, CA, USA

Publication date: September 8, 2003

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