Synthetic studies of himbacine, a potent antagonist of the muscarinic M2 subtype receptor 1. Stereoselective total synthesis and antagonistic activity of enantiomeric pairs of himbacine and (2'S,6'R)-diepihimbacine, 4-epihimbacine, and novel himbacine congeners

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Keywords: Diels-Alder reactions; alkaloids; asymmetric synthesis; natural products

Document Type: Research Article


Affiliations: Discovery Research Laboratories, Kyorin Pharmaceutical Company Ltd, 2399-1 Nogi, Nogi-machi, 329-0114, Tochigi, Japan

Publication date: December 9, 2002

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