Studies on pyrrolidinones. On the decarboxylation of pyroglutamic acids and N-acyl prolines in acidic media

Authors: Akue-Gedu, R.; Al Akoum Ebrik, S.; Witczak-Legrand, A.; Fasseur, D.; El Ghammarti, S.; Couturier, D.; Decroix, B.; Othman, M.; Debacker, M.; Rigo, B.

Source: Tetrahedron, Volume 58, Number 45, 4 November 2002 , pp. 9239-9247(9)

Publisher: Elsevier

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Keywords: Friedel-Crafts reaction; N-acyliminium salts; N-acylproline; decarbonylation; decarboxylation; lactams; pyroglutamic acid

Document Type: Research Article

DOI: http://dx.doi.org/10.1016/S0040-4020(02)01183-3

Affiliations: Groupe de Recherche sur l'Inhibition de la Proliferation Cellulaire, EA 2692, Ecole des Hautes Etudes Industrielles, 13, rue de Toul, 59046 , Lille, France

Publication date: November 4, 2002

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