Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin

Authors: Wipf, P.; Hopkins, C.R.; Phillips, E.O.; Lazo, J.S.

Source: Tetrahedron, Volume 58, Number 32, 5 August 2002 , pp. 6367-6372(6)

Publisher: Elsevier

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Keywords: Cdc25; DNA cleavage; Dnacin; PTP1B; SAR; VHR; dual specificity phosphatase inhibitors; natural product library; tyrosine phosphatase

Document Type: Research Article


Affiliations: Department of Pharmacology, University of Pittsburgh, 15261, Pittsburgh, PA, USA

Publication date: August 5, 2002

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