The mono-functionalization of symmetrical polyamines

Authors: Bender, J.A.; Meanwell, N.A.; Wang, T.

Source: Tetrahedron, Volume 58, Number 16, 15 April 2002 , pp. 3111-3128(18)

Publisher: Elsevier

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Keywords: acylation; alkylation; arylation; aza macrocycles; cyclam; cyclen; desymmetrization; diamines; piperazines; regiocontrol

Document Type: Review Article

DOI: http://dx.doi.org/10.1016/S0040-4020(02)00165-5

Affiliations: Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, 06492, Wallingford, CT, USA

Publication date: April 15, 2002

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