Synthesis, hydrolysis, biochemical and theoretical evaluation of 1,4-bis(alkoxycarbonyl)azetidin-2-ones as potential elastase inhibitors

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Keywords: -lactam; ab initio calculation; elastase; serine-protease inhibition

Document Type: Research Article

DOI: http://dx.doi.org/10.1016/S0040-4020(02)00112-6

Affiliations: Unite de Chimie Organique et Medicinale, Universite Catholique de Louvain, Batiment Lavoisier, Place Louis Pasteur 1, B-1348 , Louvain-la-Neuve, Belgium

Publication date: March 18, 2002

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