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Stereoselective conversion of 2H-1,4-oxazin-2-ones into 2,5,5-substituted piperidine-2-carboxamides and 2-methanamines and related octahydro-2H-pyrido[1,2-a]pyrazines, potential substance P antagonists

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Keywords: Diels-Alder reactions; bicyclic heterocyclic compounds; conformation; piperidines

Document Type: Research Article

DOI: http://dx.doi.org/10.1016/S0040-4020(01)00888-2

Affiliations: Laboratorium voor Organische Synthese, Department of Organic Chemistry, K.U. Leuven, Celestijnenlaan 200F, 3001 (Heverlee), Leuven, Belgium

Publication date: October 22, 2001

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