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Process development of potassium channel opener, TCV-295, based on convenient ring formation of 2H-1,3-benzoxazine and selective N-oxidation of the pyridyl moiety

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Keywords: N-oxides; amines; ammonium salts; benzoxazines; dioxiranes

Document Type: Research Article

DOI: http://dx.doi.org/10.1016/S0040-4020(01)00728-1

Affiliations: Chemical Development Laboratories, Pharmaceutical Production Division, Takeda Chemical Industries Ltd, 2-17-85 Jusohonmachi, Yodogawaku, 532 8686, Osaka, Japan

Publication date: August 27, 2001

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