Protein Backbone Engineering through Total Chemical Synthesis: New Insight into the Mechanism of HIV-1 Protease Catalysis

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Keywords: HIV-1 protease; backbone engineering; chemical ligation; chemical protein synthesis; enzyme mechanism; hydrogen bond; thioester; unprotected peptide segments

Document Type: Research Article

DOI: http://dx.doi.org/10.1016/S0040-4020(00)00835-8

Affiliations: bGryphon Sciences, Suite 90, 250 East Grand Avenue South, 94060, San Francisco, CA, USA

Publication date: November 24, 2000

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