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A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6-hydroxylation

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Keywords: Aroclor 1254; Cytochrome P450; Drug metabolism; Enzyme induction; Genotoxicity assays; Liver microsomes; Species comparisons; Xenobiotic metabolism

Document Type: Research Article

DOI: http://dx.doi.org/10.1016/S0009-2797(01)00159-4

Affiliations: In Vitro Technologies, Inc., 1450 S. Rolling Rd, 21227, Baltimore, MD, USA

Publication date: May 16, 2001

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