Mechanism-based inhibition of rat liver microsomal diazepam C₃-hydroxylase by mifepristone associated with loss of spectrally detectable cytochrome P450

Authors: Reilly P.E.B.; Gomi R.J.; Mason S.R.

Source: Chemico-Biological Interactions, Volume 118, Number 1, 1 March 1999 , pp. 39-49(11)

Publisher: Elsevier

Keywords: CYP3A; Cytochrome P450; Heme thiolate protein; Food deprivation; Diazepam C₃-hydroxylase; Mifepristone; RU486; Monooxygenase induction; Mechanism-based inhibition; Dexamethasone

Language: English

Document Type: Research article

DOI: 10.1016/S0009-2797(98)00115-X

Links for this article

http://www.ingentaconnect.com/els/00092797/1999/00000118/00000001/art00115
http://openurl.ingenta.com/content?genre=article&issn=0009-2797&volume=118&issue=1&spage=39&epage=49
http://dx.doi.org/10.1016/S0009-2797(98)00115-X

Mechanism-based inhibition of rat liver microsomal diazepam C3-hydroxylase by mifepristone associated with loss of spectrally detectable cytochrome P450