Secreted phospholipase A₂ as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue

Authors: Davidsen J.; Jorgensen K.¹; Andresen T.L.; Mouritsen O.G.

Source: Biochimica et Biophysica Acta (BBA)/Biomembranes, Volume 1609, Number 1, 10 January 2003 , pp. 95-101(7)

Publisher: Elsevier

Keywords: Drug delivery; Liposome; Phospholipase A₂; Permeability; Membrane; Surfactant; Enhancer; Lyso-phospholipid; Fatty acid

Language: English

Document Type: Research article

DOI: 10.1016/S0005-2736(02)00659-4

Affiliations: 1: LiPlasome Pharma A/S, Department of Chemistry, Technical University of Denmark, Building 207, DK-2800 , Lyngby, Denmark

Links for this article

http://www.ingentaconnect.com/els/00052736/2003/00001609/00000001/art00659
http://openurl.ingenta.com/content?genre=article&issn=0005-2736&volume=1609&issue=1&spage=95&epage=101
http://dx.doi.org/10.1016/S0005-2736(02)00659-4

Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue