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Open Access Soybean and tempeh total isoflvones improved antioxidant activities in normal and scopolamine-induced rat brain

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Objective: To highlight the comparative studies between total isoflavone extracts from soybean and tempeh on the neuronal oxidative stress and antioxidant activities. Methods: The total isoflavones were administered orally for 15 days with 3 selected doses (10, 20 and 40 mg/kg). Piracetam (400 mg/kg, p.o. ) was used as a standard drug while scopolamine (1 mg/kg, i.p.) was used as a drug that promoted amnesia in selected groups. The oxidative markers (thiobarbituric acid reactive substances and nitric oxide) were measured in brain homogenate. The antioxidant activities evaluated were catalase, superoxide dismutase, glutathione reductase and glutathione. Results: Our results showed that soybean and tempeh isoflavones significantly improved the levels of catalase, superoxide dismutase, glutathione reductase and glutathione while decreased levels of thiobarbituric acid reactive substances and nitric oxide in both the brain of normal as well as scopolamine-induced animals. Conclusions: Our findings suggested that soybean and tempeh isoflavones could be useful in the management and prevention of age-related neurodegenerative changes including Alzheimer’s disease through its antioxidant activities.
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Document Type: Research Article

Affiliations: 1: Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Brain Degeneration and Therapeutics Group, Pharmaceutical and Life Sciences Communities of Research, Universiti Teknologi MARA, 40450 Shah Alam, Selangor Darul Ehsan, Malaysia 2: Brain Degeneration and Therapeutics Group, Pharmaceutical and Life Sciences Communities of Research, Universiti Teknologi MARA, 40450 Shah Alam, Selangor Darul Ehsan, Malaysia; Collaborative Drug Discovery Research Group, Pharmaceutical and Life Sciences Communities of Research, Universiti Teknologi MARA, 40450 Shah Alam, Selangor Darul Ehsan, Malaysia

Publication date: 01 January 2015

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