The association of inherited variation in the CLOCK gene with breast cancer tumor grade
Methods: We investigated the relationship between single nucleotide polymorphisms (SNPs) in the CLOCK gene and tumor grade and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status in 293 breast cancer patients. Nine SNPs were determined by standard TaqMan assays. Tumor grade, receptor status, and other clinical variables were abstracted from medical records.
Results: Two SNPs were excluded because of poor genotyping performance. None of the remaining seven variants had a statistically significant association with breast cancer tumor grade or with receptor status.
Conclusion: As with all novel studies, further work is needed to examine the association of CLOCK and other genes in the circadian rhythm pathway with breast cancer tumor grade in other populations.
Document Type: Research Article
Publication date: 01 July 2017
This article was made available online on 03 July 2017 as a Fast Track article with title: "The association of inherited variation in the CLOCK gene with breast cancer tumor grade".
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