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Open Access Risk factors for post-operative delirium in elderly Chinese patients

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Objective: The purpose of this study was to systematically analyze the risk factors for post-operative delirium (PD) in elderly patients in an effort to provide a basis for developing relevant clinical interventions in China.

Methods: All published studies focusing on the risk factors for PD among elderly patients in Wanfant Data, China National Knowledge Infrastructure (CNKI), and VIP were collected according to the inclusion and exclusion criteria of this study. A meta-analysis was performed on case-control studies using RevMan5.2 software, and the incidence of PD risk factors was calculated among case series.

Results: Sixteen studies, including 8 case-control studies and 8 case series, were included in the current study. There were 353 cases and 2008 controls in the case-control studies. The pooled odds ratios (95% CI) of PD risk factors were as follows: hypoxemia, 2.58 (1.59~4.18); pulmonary infection, 4.51 (2.23~9.13); hypertension, 2.16 (1.20~3.89); coronary heart disease, 1.50 (0.82~2.73); post-operative pain, 3.18 (1.63~6.20); general anesthesia, 3.64 (0.94~14.11); operative time, 1.70 (0.79~3.66); and senility, 0.52 (‐0.25~1.29). The meta-analysis showed that hypoxemia, pulmonary infection, hypertension, coronary heart disease, post-operative pain, general anesthesia, operative time, and senility were significant risk factors for PD. There were 404 cases in the case series, and the incidence of hypoxemia, hypertension, general anesthesia, diabetes mellitus, senility, coronary heart disease, pulmonary infection, and cerebrovascular disease was 62.62%, 55.90%, 33.7%, 24.8%, 16.58%, 15.3%, 13.9%, and 12.1%, respectively, which was much higher than other risk factors.

Conclusion: Senility, hypertension, coronary heart disease, diabetes mellitus, pulmonary infection, hypoxemia, post-operative pain, and general anesthesia are significant risk factors for PD among elderly Chinese patients.

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Keywords: Elderly patient; Meta-analysis; Post-operative delirium; Risk factor; Systematic review

Document Type: Research Article

Publication date: 2014-12-01

More about this publication?
  • Family Medicine and Community Health (FMCH) is an open-access journal focusing on subjects that are common and relevant to family medicine/general practice and community health. The journal publishes relevant content across disciplines such as epidemiology, public health, social and preventive medicine, research and evidence based medicine, community health service, patient education and health promotion and health ethics. The journal has a specific focus on the management of chronic illness particularly diabetes, ischaemic heart disease, chronic heart failure, hypertension, bronchial asthma, chronic obstructive airways disease and common mental illness. FMCH is published by Compuscript on behalf of the Chinese General Practice Press

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