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Open Access Correlation between KCNQ1 gene polymorphism and type 2 diabetes mellitus in Huaihai region of China

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Objective: This article aims to discuss the distribution of KCNQ1 gene polymorphism in the Chinese Han population in the Huaihai region of China and the correlation between KCNQ1 gene polymorphism and incidence of type 2 diabetes (T2DM).

Methods: From December 2010 to July 2011, 200 T2DM inpatients and outpatients in the Endocrinology Department of the Affiliated Hospital of Xuzhou Medical College were selected as the case group and, 200 healthy people identified by the health examination center in the same region were selected as the control group. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) test was used to examine the gene polymorphism of the two groups.

Results: (1) Analysis on the control group showed that at the KCNQ1 rC237892 locus, the genotype frequencies of CC, CT and TT were 36.0% (72/200), 51.0% (102/200) and 13.0% (26/200) respectively, and the allelic frequencies of C and T were 61.5% (246/400) and 38.5% (154/400) respectively. Analysis on the case group showed the genotype frequencies of CC, CT and TT were 47.5% (95/200), 44.0% (88/200) and 8.5% (17/200) respectively, and the allelic frequencies of C and T were 69.5% (278/400) and 30.5% (122/400) respectively. Comparison between the genotype distributions and allelic frequencies of the two tested groups at KCNQ1 rC237892 locus showed differences with statistical significance (P <0.05). (2) Comparison between the genotype distributions and allelic C and A frequencies of the control group and the case group showed differences with no statistical significance (P>0.05).

Conclusion: Polymorphism at KCNQ1 rs2237892 locus may be correlated to the incidence of T2DM in the Chinese Han population in Huaihai region of China; polymorphism at rsl51290 locus may be irrelevant to the incidence of T2DM in the Chinese Han population in Huaihai region of China.

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Keywords: Allelic frequency; Genotype distribution; KCNQ1; Mononucleotide; Polymorphism; Type 2 diabetes mellitus

Document Type: Research Article

Publication date: 2014-03-01

More about this publication?
  • Family Medicine and Community Health (FMCH) is an open-access journal focusing on subjects that are common and relevant to family medicine/general practice and community health. The journal publishes relevant content across disciplines such as epidemiology, public health, social and preventive medicine, research and evidence based medicine, community health service, patient education and health promotion and health ethics. The journal has a specific focus on the management of chronic illness particularly diabetes, ischaemic heart disease, chronic heart failure, hypertension, bronchial asthma, chronic obstructive airways disease and common mental illness. FMCH is published by Compuscript http://www.compuscript.com on behalf of the Chinese General Practice Press http://www.chinagp.net.

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