Skip to main content

Open Access Prognostic Implications of Echocardiographic Left Ventricular Dyssynchrony

Download Article:
 Download
(HTML 55.291015625 kb)
 
or
 Download
(PDF 58002.966796875 kb)
 
Abstract

Normal regional left ventricular (LV) mechanical contraction is synchronous, resulting in efficient ejection. Abnormalities in electrical activation or myocardial diseases may affect the timing of regional contraction, resulting in discoordinated or dyssynchronous contraction, which is inefficient. This article reviews various approaches to quantify dyssynchrony, focusing on LV dyssynchrony, that have been principally related to cardiac resynchronization therapy (CRT). Several attempts have been made to improve patient selection for CRT by use of echocardiographic dyssynchrony; however, none have gained clinical acceptance. This review focuses on the different reasons for the existence LV dyssynchrony, the dyssynchronous strain patterns indicative of CRT response, and the prognostic implications of dyssynchrony. Interest in echocardiographic dyssynchrony remains high because of its mechanistic and prognostic importance. Dyssynchrony may occur from electrical or nonelectrical causes. Patients with a wide QRS complex who have baseline dyssynchrony from electrical delay in general have a favorable response to CRT, whereas patients with nonelectrical dyssynchrony (from contractile heterogeneity or scar) at the baseline have a worse prognosis. New insights into the meaning of mechanical dyssynchrony continue to emerge, and this article reviews the important lessons learned from experience, prognostic implications, and promise for future applications.
No References for this article.
No Supplementary Data.
No Data/Media
No Metrics

Keywords: Heart failure; echocardiography; pacing therapy; ventricular mechanics

Document Type: Research Article

Publication date: 2016-12-01

More about this publication?
  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Membership Information
  • Information for Advertisers
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more