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Open Access Syncope and Early Repolarization: A Benign or Dangerous ECG Finding?

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Early repolarization is a well-described, common electrocardiographic variant. It was initially felt to be benign, but in the last twenty years a suggested a link between specific types of early repolarization and sudden cardiac death has emerged. This association was has been termed the J wave syndrome and includes both the high risk early repolarization and Brugada ECG patterns. The odds of early repolarization change being associated with poor outcomes are still exceedingly small. Nevertheless, the association of a fairly ubiquitous ECG finding with fatal or near fatal clinical outcomes has raised concern. How can we identify the truly high-risk patients? If a patient has a significant clinical event with a concerning ECG repolarization pattern, what should be done next? The authors of this review present current information regarding the Early Repolarization and Brugada Syndromes and how to proceed with diagnosis, management, and risk stratification when early repolarization change is observed on ECG.

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Keywords: Brugada syndrome; J wave syndrome; early repolarization; genetic channelopathy; syncope

Document Type: Research Article

Publication date: 2016-02-01

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  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

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