Multilevel Genomic Approach in Pain Research: Basic Science and Clinical Implications

Authors: Luo, Z. David¹; Figueroa, Katherine W.²

Source: Reviews in Analgesia, Volume 10, Number 1, 2008 , pp. 45-58(14)

Publisher: Cognizant Communication Corporation

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Abstract:

The combination of microarray technologies with well-defined animal models provides unparalleled detection power to gain insights into gene expression profiles in sensory pathways responding to pain-inducing pathological conditions in a high throughput manner. This, in turn, provides critical information for further identification and characterization of differentially regulated genes and pathways that may play pivotal roles in pain processing and analgesia sensitivity. Appropriate experimental design with additional variants from animal models would allow the detection of factors and underlying pathways related to pain susceptibility and analgesic sensitivity. Clinical application of these technologies certainly improves our understanding in mechanisms of pain and analgesic actions, leading to advancements in diagnosis and prognosis as well as patient care qualities. In this review, the advantages and limitations of microarray technologies are reviewed; strategic applications of these technologies in recent preclinical and clinical researches related to mechanisms of pain and analgesic actions are summarized.

Keywords: Microarray technologies; Gene expression profiles; Sensory pathways; Analgesic actions

Document Type: Research article

Affiliations: 1: Department of Anesthesiology, School of Medicine, University of California Irvine, Irvine, CA 92697, USA, Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, CA 92697, USA 2: Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, CA 92697, USA

Publication date: 2008-01-01

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