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Downregulation of Protein Kinase Cα Was Involved in Selenite-Induced Apoptosis of NB4 Cells

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We revealed in our previous research that sodium selenite induced obvious apoptosis of human leukemia NB4 cells, with reactive oxygen species (ROS), mitochondrial apoptosis pathway, and endoplasmic reticulum stress (ER stress) involved. In the present study, we revealed protein kinase Cα (PKCα) was dramatically downregulated in selenite-induced apoptosis, which was mediated by ROS. Besides, we confirmed PKCα played an antiapoptotic role through its effects on ERK1/2 and Akt, while its downregulation was attributed to caspase-3 and PP2Ac under the regulation of ROS. In summary, we speculated that in apoptosis of NB4 cells induced by selenite, PKCα functioned to counteract apoptosis, thus its downregulation seemed a mechanism aggravating apoptosis.

Keywords: Apoptosis; Protein kinase Cα (PKCα); Reactive oxygen species (ROS); Sodium selenite

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/096504010X12864748215089

Publication date: January 1, 2010

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  • Formerly: Oncology Research Incorporating Anti-Cancer Drug Design
    Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.
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