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Downregulation of Protein Kinase Cα Was Involved in Selenite-Induced Apoptosis of NB4 Cells

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We revealed in our previous research that sodium selenite induced obvious apoptosis of human leukemia NB4 cells, with reactive oxygen species (ROS), mitochondrial apoptosis pathway, and endoplasmic reticulum stress (ER stress) involved. In the present study, we revealed protein kinase Cα (PKCα) was dramatically downregulated in selenite-induced apoptosis, which was mediated by ROS. Besides, we confirmed PKCα played an antiapoptotic role through its effects on ERK1/2 and Akt, while its downregulation was attributed to caspase-3 and PP2Ac under the regulation of ROS. In summary, we speculated that in apoptosis of NB4 cells induced by selenite, PKCα functioned to counteract apoptosis, thus its downregulation seemed a mechanism aggravating apoptosis.

Keywords: Apoptosis; Protein kinase Cα (PKCα); Reactive oxygen species (ROS); Sodium selenite

Document Type: Research Article


Publication date: 2010-02-01

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