Clinical and Biological Relationship Between Chronic Lymphocytic Thyroiditis and Papillary Thyroid Carcinoma

Authors: Antonaci, Alfredo; Consorti, Fabrizio; Mardente, Stefania; Giovannone, Gloria

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Volume 17, Number 10, 2009 , pp. 495-503(9)

Publisher: Cognizant Communication Corporation

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Abstract:

The association between chronic lymphocytic thyroiditis and papillary thyroid carcinoma has been investigated for several years from different perspectives but with few attempts to design a common frame of reference to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression. This article reviews the current knowledge and research on this topic according to epidemiologic, immunobiologic, pathologic, and biomolecular points of view, highlighting achievements and lack of knowledge. It draws some conclusions and points at possible future directions for research.

Keywords: Chronic lymphocytic thyroiditis; Papillary thyroid carcinoma; Oncogenes; Apoptosis

Document Type: Research article

DOI: http://dx.doi.org/10.3727/096504009789735431

Publication date: 2009-10-01

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Formerly: Oncology Research Incorporating Anti-Cancer Drug Design
Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.