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Transcriptional Activation of hTERT in Breast Carcinomas by the Her2-ER81-Related Pathway

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Her2 and ER81 (a member of ETS family) have been suggested to cause a synergistic increase in the transcriptional activation of hTERT. Our study aimed to offer further confirmation in clinical material. We determined the mRNA levels of Her2, ER81, and hTERT, by QRT-PCR, in 43 breast carcinomas. In the specimens showing hTERT transcriptional activation, Her2 and ER81 were increased in statistically significant tumor subgroups (61% and 79% correspondingly). The 86% of specimens with both Her2 and ER81 increased expression showed hTERT transcriptional activation. Synchronous transcriptional activation of hTERT, Her2, and ER81 elevated expression was noted in 42% of the samples. In conclusion, we agree with a previous study that Her2 overexpression may increase the hTERT transcriptional activation. Our data indicate that the mechanism may involve Her2‐ER81 interaction(s) and that the activation of hTERT could be mainly mediated by transcriptional activation of ER81.

Keywords: ER81; Her2; Q-RT real-time PCR; hTERT

Document Type: Research Article


Publication date: 2009-09-01

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