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Endothelin-1 Inhibition by Ambrisentan as a Potential Treatment Adjunct After Debulking Surgery in Epithelial Ovarian Cancer

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Abstract:

The 21 amino acid signaling peptide endothelin-1 is commonly elevated in epithelial ovarian cancer, and it mediates or facilitates much of this cancer's aggressive behavior. Ambrisentan (Letairis; Gilead Sciences Inc.) is an antagonist of endothelin-1 at its cognate receptor that has just been approved to treat pulmonary hypertension. Ambrisentan is a well-tolerated pill taken once daily. In theory, it should retard and inhibit lodgement and establishment of disseminated peritoneal micrometastases after debulking surgery.

Keywords: Ambrisentan; Endothelin; Epithelial ovarian cancer; Metaplasia; Micrometastases

Document Type: Commentary

DOI: https://doi.org/10.3727/096504009788428433

Publication date: 2009-01-01

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