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COX-2 Polymorphisms in Patients With Familial Adenomatous Polyposis

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Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as inflammation, cell proliferation, and angiogenesis. COX-2 has been found overexpressed in (pre)malignant tissues and may be relevant to cancer development. We investigated whether functional genetic polymorphisms in COX-2 may have a risk-modifying effect on duodenal adenomatosis in patients with familial adenomatous polyposis (FAP). Blood from 85 patients with FAP and 218 age- and sex-matched healthy subjects was investigated for the presence of two functional promoter region polymorphisms (−1195G → A and −765G → C) in COX-2. Logistic regression analysis revealed an overrepresentation of the −1195GG genotype compared to the −1195AA genotype in patients with FAP (odds ratio = 2.81; 95% CI = 1.00‐7.91, p = 0.042). No associations between single COX-2 polymorphisms or COX-2 haplotype were found when patients were evaluated according to their Spigelman stage. The predicted low COX-2 expression genotype −1195GG was found overrepresented in the patients with FAP. The COX-2 genotypes showed no association with the severity of duodenal adenomatosis.
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Keywords: Cyclooxygenase-2; Duodenal adenomatosis; Familial adenomatous polyposis; Genetic polymorphism

Document Type: Research Article

Publication date: 2009-01-01

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