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Radiation-Induced Antitumor Properties of Vitamin B5 (Pantothenic Acid) and its Effect on Mitomycin C Activity: Experiments In Vitro

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Abstract:

Vitamin B5 (pantothenic acid) shows a strongly pronounced antitumor effect under the influence of ionizing radiation. In the frame of experiments in vitro (model: Escherichia coli bacteria, AB1157) performed under the exact knowledge of concentration and kind of the free radicals acting in the various aqueous media (pH 7.4) the following was established: (i) vitamin B5 possesses a very intense antitumor property, (ii) it exerts a strong synergistic effect on mitomycin C (MMC), (iii) the oxidizing species (OH, O2 •−) appears to be most important in the initiation of the observed effect. The generated radiolytic products from vitamin B5 very likely also play an important role in this respect.

Keywords: Antitumor effect; Pantothenic acid; Synergistic action of vitamin B5; Vitamin B5

Document Type: Research Article

DOI: https://doi.org/10.3727/000000006783980919

Affiliations: Section Radiation Biology, Department of Nutrition Sciences, The University of Vienna, A-1090 Vienna, Austria

Publication date: 2006-08-01

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