Radiation-Induced Antitumor Properties of Vitamin B5 (Pantothenic Acid) and its Effect on Mitomycin C Activity: Experiments In Vitro
Abstract:Vitamin B5 (pantothenic acid) shows a strongly pronounced antitumor effect under the influence of ionizing radiation. In the frame of experiments in vitro (model: Escherichia coli bacteria, AB1157) performed under the exact knowledge of concentration and kind of the free radicals acting in the various aqueous media (pH 7.4) the following was established: (i) vitamin B5 possesses a very intense antitumor property, (ii) it exerts a strong synergistic effect on mitomycin C (MMC), (iii) the oxidizing species (OH•, O2 •−) appears to be most important in the initiation of the observed effect. The generated radiolytic products from vitamin B5 very likely also play an important role in this respect.
Document Type: Research Article
Affiliations: Section Radiation Biology, Department of Nutrition Sciences, The University of Vienna, A-1090 Vienna, Austria
Publication date: 2006-08-01
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