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Pu-erh Tea Supplementation Suppresses Fatty Acid Synthase Expression in the Rat Liver Through Downregulating Akt and JNK Signalings as Demonstrated in Human Hepatoma HepG2 Cells

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Abstract:

Fatty acid synthase (FAS) is a key enzyme of lipogenesis. Overexpression of FAS is dominant in cancer cells and proliferative tissues. The expression of FAS in the livers of rats fed pu-erh tea leaves was significantly suppressed. The gains in body weight, levels of triacylglycerol, and total cholesterol were also suppressed in the tea-treated rats. FAS expression in hepatoma HepG2 cells was suppressed by the extracts of pu-erh tea at both the protein and mRNA levels. FAS expression in HepG2 cells was strongly inhibited by PI3K inhibitor LY294002 and JNK inhibitor II and slightly inhibited by p38 inhibitor SB203580 and MEK inhibitor PD98059, separately. Based on these findings, we suggest that the suppression of FAS in the livers of rats fed pu-erh tea leaves may occur through downregulation of the PI3K/AKt and JNK signaling pathways. The major components of tea that have been demonstrated to be responsible for the antiobesity and hypolipidemic effects are catechins, caffeine, and theanine. The compositions of catechins, caffeine, and theanine varied dramatically in pu-erh, black, oolong, and green teas. The active principles and molecular mechanisms that exerted these biological effects in pu-erh tea deserve future exploration.

Keywords: Akt signaling; Anticancer; Antiobesity; Black tea; Fatty acid synthase (FAS); Green tea; HepG2 cells; JNK signaling; Oolong tea; Pu-erh tea

Document Type: Research Article

DOI: https://doi.org/10.3727/000000006783981143

Affiliations: 1: Institute of Biochemistry and Molecular Biology, College of Medicine National Taiwan University, Taipei, Taiwan 2: Institute of Pharmacology, College of Medicine National Taiwan University, Taipei, Taiwan 3: Wun-Shan Branch, Tea Research and Extension Station, Taipei, Taiwan

Publication date: 2006-03-01

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