IngentaConnect PhosphorSulphur Ratio: An Indicator of Malignant Uterus Change

Authors: Patai, Kálmán¹; Dévényi, László²; Hubay, Márta³; Csömör, Sándor¹; Zelkó, Romána⁴

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Volume 15, Number 4, 2005 , pp. 215-217(3)

Publisher: Cognizant Communication Corporation

Abstract:

The purpose of the present study was to establish a correlation between gynaecological diseases (myoma, adenocarcinoma) and phosphor/sulphur (P/S) ratios of different regions of the uterus. Routine histological specimens were reexamined with the intention to select representative regions of the uteruses for element analysis. Conventional hematoxylin-eosin-stained sections were used to identify histological alterations by light microscopy. Scanning electron microscopic (SEM) and energy-dispersive spectroscopic (EDS) investigations were carried out to analyze the morphology and the related element composition of the samples. The results of the nonparametric statistical test (Wilcoxon rank-sum test) indicate that the P/S ratios were significantly higher in adenocarcinoma (0.8891 ± 0.0757) than in myoma (0.4713 ± 0.0306). P/S ratios of different pathologic regions of uteruses seem worth examining in a larger study population. Combination of routine histological examinations with element analysis of specimens may have useful applications in patients who have undergone radiation therapy and may identify a pattern for local recurrence at certain sites.

Keywords: Myoma; Adenocarcinoma; Phosphor/sulpur ratio; Energy dispersive X-ray spectroscopy

Document Type: Research article

Affiliations: 1: Second Department of Obstetrics and Gynaecology, Semmelweis University, 78/a Üllöi Street, H-1082 Budapest, Hungary 2: Department of Materials Science and Engineering, Budapest University of Technology and Economics, 3.Goldmann Sq., 1111 Budapest, Hungary 3: Department of Forensic Medicine, Semmelweis University, Üllöi Street 93, 1091 Budapest, Hungary 4: University Pharmacy, Department of Pharmacy Administration, Semmelweis University, 7-9. Högyes E. Street, 1092 Budapest, Hungary

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Phosphor/Sulphur Ratio: An Indicator of Malignant Uterus Change