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Phosphor/Sulphur Ratio: An Indicator of Malignant Uterus Change

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Abstract:

The purpose of the present study was to establish a correlation between gynaecological diseases (myoma, adenocarcinoma) and phosphor/sulphur (P/S) ratios of different regions of the uterus. Routine histological specimens were reexamined with the intention to select representative regions of the uteruses for element analysis. Conventional hematoxylin-eosin-stained sections were used to identify histological alterations by light microscopy. Scanning electron microscopic (SEM) and energy-dispersive spectroscopic (EDS) investigations were carried out to analyze the morphology and the related element composition of the samples. The results of the nonparametric statistical test (Wilcoxon rank-sum test) indicate that the P/S ratios were significantly higher in adenocarcinoma (0.8891 ± 0.0757) than in myoma (0.4713 ± 0.0306). P/S ratios of different pathologic regions of uteruses seem worth examining in a larger study population. Combination of routine histological examinations with element analysis of specimens may have useful applications in patients who have undergone radiation therapy and may identify a pattern for local recurrence at certain sites.

Keywords: Adenocarcinoma; Energy dispersive X-ray spectroscopy; Myoma; Phosphor/sulpur ratio

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/096504005776382279

Affiliations: 1: Second Department of Obstetrics and Gynaecology, Semmelweis University, 78/a Üllöi Street, H-1082 Budapest, Hungary 2: Department of Materials Science and Engineering, Budapest University of Technology and Economics, 3.Goldmann Sq., 1111 Budapest, Hungary 3: Department of Forensic Medicine, Semmelweis University, Üllöi Street 93, 1091 Budapest, Hungary 4: University Pharmacy, Department of Pharmacy Administration, Semmelweis University, 7-9. Högyes E. Street, 1092 Budapest, Hungary

Publication date: April 1, 2005

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  • Formerly: Oncology Research Incorporating Anti-Cancer Drug Design
    Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.
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