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Mutational Alterations of the p16CDKN2A Tumor Suppressor Gene Have Low Incidence in Mesenchymal Chondrosarcoma

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Abstract:

Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16INK4A/MTS1) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in mesenchymal chondrosarcoma, alterations of CDKIs were examined in human mesenchymal chondrosarcoma tissues using a quantitative DNA/PCR, PCR-SSCP. Seven of 33 specimens (21.2%) showed abnormally low levels of p16CDKN2A amplification, suggesting that the allelic deletion of the gene might be a less frequent event in progression of this tumor. To detect subtle sequence alterations such as point mutations, SSCP analysis of the entire coding region of the p16CDKN2A gene, exons 1, 2, and 3 regions, showed no altered SSCP patterns in 33 mesenchymal chondrosarcoma specimens. A low incidence of genetic alterations of the p16CDKN2A was found in mesenchymal chondrosarcoma. Through this study, we conclude that alteration of the p16CDKN2A gene does not participate significantly in the tumorigenesis of mesenchymal chondrosarcoma.

Keywords: Key words: p16CDKN2A tumor suppressor gene; Mesenc

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/000000001108747381

Affiliations: 1: *Department of Orthopedic Surgery, College of Medicine, Kyung Hee University, Seoul, Korea 2: †Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Korea 3: ‡Department of Pathology, Mayo Clinic, Mayo Foundation, Rochester, MN

Publication date: January 1, 2001

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  • Formerly: Oncology Research Incorporating Anti-Cancer Drug Design
    Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.
cog/or/2001/00000012/00000001/or205
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