Adult Neurogenesis and Dendritic Remodeling in Hippocampal Plasticity: Which One Is More Important?
Abstract:Accumulating knowledge has shown that a decrease in hippocampal neurogenesis is linked to the pathophysiology of mood disorders and some hippocampal-dependent learning and memory tasks. The role of adult neurogenesis has initially been proposed based on correlations between decreases or increases in neurogenesis and impairments or improvements, respectively, in animal behaviors following interventions. Its role has been further elucidated through the ablation of neurogenesis. However, the functional roles of neurogenesis in hippocampal-dependent behaviors have been challenged by inconsistent findings between different studies. Despite the fact that factors affecting neurogenesis also induce dendritic or synaptic changes in newborn or existing neurons, these two aspects of structural changes within the hippocampus have always been examined separately. Thus, it is difficult to interpret the functional role of adult neurogenesis or dendritic remodification in hippocampal-dependent behaviors. This review discusses the relative contribution of adult neurogenesis and dendritic/synaptic remodeling of existing neurons to hippocampal plasticity.
Document Type: Research Article
Affiliations: Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong
Publication date: 2014-04-09
More about this publication?
- Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.