In Situ Electrostimulation Drives a Regenerative Shift in the Zone of Infarcted Myocardium
Authors: Spadaccio, Cristiano; Rainer, Alberto; De Marco, Federico; Lusini, Mario; Gallo, Paolo; Sedati, Pietro; Muda, Andrea Onetti; De Porcellinis, Stefano; Gregorj, Chiara; Avvisati, Giuseppe; Trombetta, Marcella; Chello, Massimo; Covino, Elvio; Bull, David A.; Patel, Amit N.; Genovese, Jorge A.
Source: Cell Transplantation, Volume 22, Number 3, 2013 , pp. 493-503(11)
Publisher: Cognizant Communication Corporation
Abstract:Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.
Document Type: Research Article
Affiliations: Center for Integrated Research, Department of Cardiovascular Science, Unit of Cardiac Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
Publication date: 2013
- Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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- In this Subject: Anatomy & Physiology , Biology , Biotechnology , Pharmacology , Surgery
- By this author: Spadaccio, Cristiano ; Rainer, Alberto ; De Marco, Federico ; Lusini, Mario ; Gallo, Paolo ; Sedati, Pietro ; Muda, Andrea Onetti ; De Porcellinis, Stefano ; Gregorj, Chiara ; Avvisati, Giuseppe ; Trombetta, Marcella ; Chello, Massimo ; Covino, Elvio ; Bull, David A. ; Patel, Amit N. ; Genovese, Jorge A.