Preservation by Desiccation of Isolated Rat Hearts for 48 Hours Using Carbon Monoxide (PCO = 4,000 hPa) and Oxygen (PO2 = 3,000 hPa)
Abstract:It is currently said that CO has anti-inflammatory and antiapoptosis effects and it has attracted attention as a medical gas. We used CO for rat hearts and conducted a preservation experiment. We isolated rat hearts, placed them into a specially made chamber, filled the chamber with a gas mixture of PCO (4,000 hPa) and PO2 (3,000 hPa), and preserved the hearts in a refrigerator at 4°C for 48 h. We then performed a heterotrophic transplantation on the neck of each recipient rat and resuscitated the preserved hearts. We herein report our findings.
Document Type: Research Article
Affiliations: Department of Anatomy, Tokyo Medical University, Tokyo, Japan
Publication date: February 1, 2012
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